Malaria
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania.
|
29381699 |
2018 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Current knowledge of the genetic basis of parasitemia levels and IgG levels is reviewed through key examples including the hemoglobinopathies, showing that the protective effect of HBB variants on malaria clinical phenotypes may partially be mediated through parasitemia and cytophilic IgG levels.
|
25887595 |
2015 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Sickle cell disease (SCD), caused by a mutation in the β-globin gene HBB, is widely distributed in malaria endemic regions.
|
24361300 |
2014 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria.
|
22506028 |
2012 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study indicates two novel resistance loci for severe malaria.
|
22895189 |
2012 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examine variants in HBB that have been shown to be protective against malaria and test whether these are associated with the transmission of the parasite from the human host to the Anopheles vector.
|
20305663 |
2010 |
Malaria
|
0.500 |
Biomarker
|
disease |
LHGDN |
Sickle cell trait (HbAS) and stunting in children below two years of age in an area of high malaria transmission.
|
19149873 |
2009 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide and fine-resolution association analysis of malaria in West Africa.
|
19465909 |
2009 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We find no evidence of the major deleterious mutations at HBB (beta-globin) and G6PD in chimpanzees that confer resistance to malaria caused by P. falciparum nor evidence of long-term balancing selection at these loci.
|
19631293 |
2009 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We replicated associations at HBB (P=.0008) and CD36 (P=.03) but also showed that the same variants are unusually differentiated in frequency between the Luo and Yoruba (who historically have been exposed to malaria) and the Masai and Kikuyu (who have not been exposed).
|
17668374 |
2007 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in the beta-globin gene (hemoglobin S) has been associated with protection against severe forms of malaria.
|
16356497 |
2006 |
Malaria
|
0.500 |
Biomarker
|
disease |
BEFREE |
It is hypothesized that repeat units or alleles of microsatellites TH01 and D5S818, located in close proximity to beta-globin gene and immune regulatory region in human play a role in malaria predisposition.
|
16216127 |
2005 |
Malaria
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To test the model, we analyzed the relationships between the polymorphisms at the hemoglobin beta chain (HBB) and red cell glutathione peroxidase (GPX1) loci in 18 populations that had been subjected to endemic malaria (Cameroon and Central African Republic).
|
10380369 |
1999 |
Malaria
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|