Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is important because it provides a better understanding of the function and role of HBZ in downregulating viral transcription and, hence, its contribution to viral latency and persistence <i>in vivo</i>, a process that may ultimately lead to the development of ATL.
|
31142665 |
2019 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the role of HBZ on ATL-associated bone destruction using HTLV-1 infection and disease progression mouse models.
|
31578308 |
2019 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Murine ATL models include transgenic animals for the viral proteins Tax and HBZ, knock-outs for key cellular regulators, xenografts and humanized immune-deficient mice.
|
29643841 |
2018 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The HBZ expression in ATLL (101.76 ± 61.3) was radically higher than in ACs (0.12 ± 0.05) and HAM/TSP (0.01 ± 0.1) (P = 0.001).
|
30577817 |
2018 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive and Negative Regulation of Type I Interferons by the Human T Cell Leukemia Virus Antisense Protein HBZ.
|
28768861 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A long latency period from HTLV-1 infection to ATL onset suggests that not only HTLV-1 proteins, such as Tax and HBZ, but also additional genetic and/or epigenetic events are required for ATL development.
|
28627735 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we revealed that HTLV-1 bZIP factor (HBZ) protein which is expressed in all ATL cases physically interacts with NRF-1 and inhibits the DNA-binding ability of NRF-1.
|
28993637 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HBZ, HTLV-1 basic leucine zipper transcription factor, promotes tumor cell proliferation and disrupts Wnt pathway modulators; however, its role in ATL induced osteolytic bone loss is unknown.
|
29050201 |
2017 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We showed that the expression of miRNAs and Dicer1 were downregulated in cells lines expressing HBZ as well as in fresh CD4 (+) cells from acute ATL patients.
|
26849145 |
2016 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, HBZ is expressed in both untransformed infected cells and ATLL cells and is involved in sustaining cell proliferation and silencing virus expression.
|
25205102 |
2014 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular study of HBZ and gp21 human T cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals.
|
23800288 |
2013 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, repressive modifications are not known to occur on the hbz promoter located in the 3' LTR, and hbz expression has been consistently detected in all ATL patient samples.
|
22696638 |
2012 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The HTLV-1 basic leucine zipper factor (HBZ) gene is encoded in the minus strand of the viral DNA and is constitutively expressed in infected cells and ATL cells.
|
22123848 |
2012 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The HTLV-1 bZIP factor (HBZ) gene, which is encoded by the minus strand of the viral genome, is expressed as an antisense transcript in all ATL cases.
|
21414204 |
2011 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy.
|
21119600 |
2011 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This method showed that all cases (n = 19) were positive for the ATLL cell line (MT-1, MT-2, and MT-4) and ATLL mouse model (HBZ-Tg mice and NOD/SCID/β2-microglobulin(null) mice with ATLL transplanted), and the HBZ gene was also detected in all human ATLL cases (n = 16).
|
21453388 |
2011 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
And then a probable mechanism of pathogenesis of ATL is proposed including recent findings on HBZ after our efforts.
|
20154469 |
2010 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In most adult T-cell leukemia (ATL) cells, Tax oncoprotein expression is typically low or undetectable, whereas Hbz gene expression is maintained, suggesting that Hbz expression may support infected cell survival and, ultimately, leukemogenesis.
|
18689544 |
2008 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Does the HBZ gene represent a new potential target for the treatment of adult T-cell leukemia?
|
18027202 |
2008 |
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
HBZ, a new important player in the mystery of adult T-cell leukemia.
|
16917009 |
2006 |