The present study investigated cerebrospinal-fluid (CSF) β-amyloid<sub>40</sub> (Aβ<sub>40</sub>), β-amyloid<sub>42</sub> (Aβ<sub>42</sub>) and orexin levels in OSA patients compared to AD patients and controls.
Multivariate unconditional logistic regression analysis adjusted for gender and age was used to estimate the associations of single nucleotide polymorphisms (SNPs) rs29230 (GABBR1), rs1801278 (IRS-1), and rs9902709 (HCRT) with OSAHS risk.
Our genetic association study, followed by functional and quantitative phenotyping assays, demonstrated a functional locus within the HCRT gene, which may act to increase HCRT expression and lead to a protective effect against the development of OSAS.