|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
[2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ.
|
17999203 |
2007 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
[2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ.
|
17999203 |
2007 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Screening of the orexin signaling system detected a 408 isoleucine to valine mutation in HCRTR1 that showed significant genotypic association with polydipsic-hyponatremic schizophrenia (p = .012).
|
15978554 |
2005 |
|
Mood Disorders
|
0.320 |
GeneticVariation
|
group |
BEFREE |
Our study suggests that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders.
|
21071097 |
2011 |
|
Mood Disorders
|
0.320 |
GeneticVariation
|
group |
BEFREE |
An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders.
|
30742846 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets.
|
29186694 |
2017 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Anxiety
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
|
30718541 |
2019 |
|
Anxiety Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
|
30718541 |
2019 |
|
Migraine Disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the serotonin transporter gene (<i>SLC6A4</i>) and the hypocretin receptor 1 gene (<i>HCRTR1</i>) may be risk factors for migraine development due to their ability to affect serotonin and hypocretin-1 (HCRT-1) concentrations.
|
29922128 |
2018 |
|
Migraine Disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders.
|
30742846 |
2019 |
|
Migraine Disorders
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.
|
21344296 |
2011 |
|
Narcolepsy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.
|
11723285 |
2001 |
|
Agoraphobia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In sum, the present results provide converging evidence for an involvement of HCRTR1 gene variation in the etiology of PD/AG and PD/AG-related traits as well as treatment response to CBT, supporting future therapeutic approaches targeting the orexin-related arousal system.
|
30718541 |
2019 |
|
Hyponatremia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
[2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ.
|
17999203 |
2007 |
|
Panic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In sum, the present results provide converging evidence for an involvement of HCRTR1 gene variation in the etiology of PD/AG and PD/AG-related traits as well as treatment response to CBT, supporting future therapeutic approaches targeting the orexin-related arousal system.
|
30718541 |
2019 |
|
Post-Traumatic Stress Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, a significant interaction effect between GHRL rs696217 and HCRTR1 rs2271933 was found to predict the PTSD Checklist (PCL-5) total score (P = 0.007).
|
30326460 |
2019 |
|
Polydipsia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
(2005) previously demonstrated an association between the 408Val allele of the HCRTR1 gene and polydipsia.In contrast with Meerabux et al. study, we found that the 408Ile allele was associated with polydipsia in our sample (chi2 = 8.00, df = 1, P = 0.0047; OR = 0.53; 95%CI = 0.34-0.83).
|
17999203 |
2007 |
|
Panic disorder with agoraphobia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
|
30718541 |
2019 |
|
Common Migraine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.
|
21344296 |
2011 |
|
Major Depressive Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hence, we conducted experiments to determine whether orexin receptor 1 and 2 (<i>Orx<sub>1</sub></i>, <i>Orx<sub>2</sub></i>) genes were associated with MDD development.
|
30596528 |
2019 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Screening of the orexin signaling system detected a 408 isoleucine to valine mutation in HCRTR1 that showed significant genotypic association with polydipsic-hyponatremic schizophrenia (p = .012).
|
15978554 |
2005 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
[2005 Biol Psychiatry 58 401-407] reported an association between the 408Val allele of the orexin 1 receptor (HCRTR1) gene and polydipsia-hyponatremia in a sample of Japanese patients with SCZ.
|
17999203 |
2007 |
|
Mood Disorders
|
0.320 |
Biomarker
|
group |
PSYGENET |
Our study suggests that the HCRTR1 gene or a linked locus may modulate the risk for Major Mood Disorders and supports recent studies suggesting an involvement of hypocretin neurotransmitter system in affective disorders.
|
21071097 |
2011 |
|
Substance Withdrawal Syndrome
|
0.310 |
Biomarker
|
disease |
CTD_human |
Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats.
|
20667500 |
2010 |