|
Absence of sensation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Age-related decrease in OX1R expression is associated with delayed emergence from isoflurane anaesthesia in aged rats.
|
30336854 |
2018 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this regard, studies on both orexin-1 receptors (OX1Rs) and orexin-2 receptors (OX2Rs) have shown some positive results, suggesting that single orexin receptor antagonists (SORAs) and dual orexin receptor antagonists (DORAs) may hold promising efficacy in the treatment of addiction compared to the currently used methods.
|
30476469 |
2020 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
All adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas, compared with normal adrenal cortex.
|
15797953 |
2005 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we demonstrated by RT-PCR the expression of the OX2-R, but not the OX1-R, gene in 10 benign secreting pheochromocytomas.
|
11600547 |
2001 |
|
Agoraphobia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In sum, the present results provide converging evidence for an involvement of HCRTR1 gene variation in the etiology of PD/AG and PD/AG-related traits as well as treatment response to CBT, supporting future therapeutic approaches targeting the orexin-related arousal system.
|
30718541 |
2019 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
This implicates the ORX system in the pathological motivation underlying alcohol abuse and alcoholism and demonstrates that the OX1R may be an important target for treating alcohol abuse.
|
27771284 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
This implicates the ORX system in the pathological motivation underlying alcohol abuse and alcoholism and demonstrates that the OX1R may be an important target for treating alcohol abuse.
|
27771284 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ninety-six percent of PDAC expressed OX1R, while adjacent normal exocrine pancreas did not.
|
29467942 |
2018 |
|
Anxiety
|
0.040 |
Biomarker
|
disease |
BEFREE |
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
|
27739093 |
2017 |
|
Anxiety
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
|
30718541 |
2019 |
|
Anxiety
|
0.040 |
Biomarker
|
disease |
BEFREE |
In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats.
|
30587409 |
2019 |
|
Anxiety
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results together suggest that orexinergic modulation of DRN 5-HT neurons via OX1Rs may be one pathway through which orexin regulates mood and anxiety, as well as perhaps other neurobiological processes.
|
31445011 |
2019 |
|
Anxiety Disorders
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
|
30718541 |
2019 |
|
Anxiety Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
These results together suggest that orexinergic modulation of DRN 5-HT neurons via OX1Rs may be one pathway through which orexin regulates mood and anxiety, as well as perhaps other neurobiological processes.
|
31445011 |
2019 |
|
Anxiety Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
SB-334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol-kindled rats.
|
27739093 |
2017 |
|
Anxiety Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats.
|
30587409 |
2019 |
|
Bone Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Based on these findings, we concluded that activation of OX1R by orexin-A might possess a therapeutic strategy for bone disease.© 2018 IUBMB Life, 70(7):633-641, 2018.
|
29999239 |
2018 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings revealed that the stimulation of OX1R might be important for tumorigenesis in pancreatic cancer and is a potential target for the treatment of patients with pancreatic cancer.
|
30429828 |
2018 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This suggests that ghrelin GHSR1a/OX1R heterodimers promotes an upregulation of a Gαs-cAMP-cAMP-responsive element signaling pathway <i>in vitro</i> and an increase in neuroblastoma cell proliferation.
|
30065627 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This suggests that ghrelin GHSR1a/OX1R heterodimers promotes an upregulation of a Gαs-cAMP-cAMP-responsive element signaling pathway <i>in vitro</i> and an increase in neuroblastoma cell proliferation.
|
30065627 |
2018 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
|
16357203 |
2005 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
|
19591850 |
2010 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.
|
19741128 |
2009 |
|
Cocaine Dependence
|
0.310 |
Biomarker
|
disease |
CTD_human |
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
|
16357203 |
2005 |
|
Cocaine Dependence
|
0.310 |
Biomarker
|
disease |
CTD_human |
Orexin/hypocretin is necessary for context-driven cocaine-seeking.
|
19591850 |
2010 |