HCRTR1, hypocretin receptor 1, 3061

N. diseases: 71; N. variants: 6
Disease: Migraine Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.030 GeneticVariation group BEFREE An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders. 30742846 2019
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.030 GeneticVariation group BEFREE Polymorphisms in the serotonin transporter gene (<i>SLC6A4</i>) and the hypocretin receptor 1 gene (<i>HCRTR1</i>) may be risk factors for migraine development due to their ability to affect serotonin and hypocretin-1 (HCRT-1) concentrations. 29922128 2018
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		0.030 GeneticVariation group BEFREE In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine. 21344296 2011