HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE Inhibition of HDAC1/2/3 caused sensitization of melanoma cells to temozolomide in vitro and in melanoma xenografts in vivo HDAC1/2/3 inhibition resulted in suppression of DNA double-strand break (DSB) repair by homologous recombination because of downregulation of RAD51 and FANCD2. 26980768 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.030 AlteredExpression disease BEFREE In HCC cells, cytosolic CPE-ΔN was translocated to the nucleus and interacted with histone deacetylase 1/2 to upregulate expression of the gene encoding neural precursor cell expressed, developmentally downregulated gene 9 (Nedd9)--which has been shown to promote melanoma metastasis. 21285511 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease LHGDN Melanoma senescence: HDAC1 in focus. 17850504 2007