HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 AlteredExpression disease BEFREE We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. 30530989 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE Together, these findings suggest that HDAC2 may represent a novel target to improve synaptic plasticity and cognition in treated schizophrenia patients. 30025863 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 AlteredExpression disease BEFREE In adult-age DLPFC, HDAC2 was decreased by 34% in schizophrenia samples compared to controls (p < 10<sup>-4</sup>). 27959513 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE Our results provide preliminary evidence that HDAC2 may not confer susceptibility to SCZ in Han Chinese. 26063464 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE In addition, the TDT did not show any significant associations between HDAC2 and HDAC3 SNPs and schizophrenia (P > 0.05). 23857786 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET These observations support the view of HDAC2 as a promising new target for schizophrenia treatment. 22864611 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE These observations support the view of HDAC2 as a promising new target for schizophrenia treatment. 22864611 2012