HDC, histidine decarboxylase, 3067

N. diseases: 92; N. variants: 7
Disease: Malignant neoplasm of colon and/or rectum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b<sup>+</sup>Gr-1<sup>+</sup> immature myeloid cells, indicating a potential antitumorigenic effect of histamine. 28917668 2017