|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Complement factor H (CFH), an inhibitor of complement activation, is involved in the pathogenesis of various renal diseases.
|
30642982 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome.
|
31524260 |
2019 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Factor H is a circulating complement regulatory protein, and congenital or acquired deficiency of factor H is a strong risk factor for several types of kidney disease.
|
29389016 |
2018 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We report pathologic changes in eyes of an fH and fP double-mutant mouse, which we previously showed have dense deposits in the GBM and early mortality from nephropathy.
|
30025090 |
2018 |
|
Kidney Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
MSCs suppressed systemic and intrarenal activation of C5, increased the plasma levels of factor H (FH), and ameliorated renal disease in lupus mice.
|
29885865 |
2018 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The role of P in atypical hemolytic uremic syndrome (aHUS) is uncertain.<b>Methods</b> We blocked P function by genetic deletion or mAb-mediated inhibition in mice carrying a factor H (FH) point mutation, W1206R (FH<sup>R/R</sup>), that causes aHUS and systemic thrombophilia with high mortality.<b>Results</b> P deficiency completely rescued FH<sup>R/R</sup> mice from premature death and prevented thrombocytopenia, hemolytic anemia, and renal disease.
|
29858280 |
2018 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Confirming this hypothesis, could have significant implications for the study of Complement Factor- H Related Proteins (CFHRs) in renal diseases and rickettsial molecular microbiology.
|
28012611 |
2017 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CKD stage, the underlying renal disease (HUS; glomerular diseases; abnormalities of kidney and urinary tract or polycystic kidney disease) and the presence of a functional renal transplant were considered as classifiers.
|
28570715 |
2017 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A haplotype in CFH family genes confers high risk of rare glomerular nephropathies.
|
28729648 |
2017 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Molecular Basis of Factor H R1210C Association with Ocular and Renal Diseases.
|
26376859 |
2016 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Mutations in fH associate with several human kidney diseases, but whether inhibiting properdin would be beneficial in these diseases is unknown.
|
23204401 |
2013 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We report the case of a boy with a novel CFH gene mutation who presented with a membranoproliferative (MPGN) pattern of glomerular injury and developed 2 years later atypical hemolytic uremic syndrome (aHUS); this description shows that CFH alteration leads to two different renal diseases in the same patient.
|
22669321 |
2012 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
|
21399633 |
2011 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
|
21399633 |
2011 |
|
Kidney Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A rare variant in CFH directly links age-related macular degeneration with rare glomerular nephropathies.
|
22120053 |
2011 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
In this paper we review the associations between human factor H dysfunction and renal disease and explore how observations in both spontaneous and engineered animal models of factor H dysfunction have contributed to our understanding of the pathogenesis of factor H-related renal disease.
|
18190458 |
2008 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Translational mini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis.
|
18070148 |
2008 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
This report emphasizes the variability in the clinical progression of kidney diseases associated with FH deficiencies.
|
14978182 |
2004 |
|
Kidney Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Factor H and the pathogenesis of renal diseases.
|
10975323 |
2000 |