|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CFH and ARMS2 risk alleles do not modify the response to the AREDS2 nutrient supplements with respect to the progression to late AMD (GA and neovascular AMD).
|
31358387 |
2019 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A sensitivity analysis of genetic variants known to be associated with late stage AMD showed that rs1061170 (p.Y402H) in the complement factor H (CFH) gene influences the association of Cer d18:1/16:0 with GA. To understand the possible influence of this genetic variant on ceramide levels, we established a cell-based assay to test the modulation of genes in the ceramide metabolism by factor H-like protein 1 (FHL-1), an alternative splicing variant of CFH that also harbors the 402 residue.
|
30071029 |
2018 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A statistically significant difference in allele frequencies between dt-GA and ndt-GA were found for CFH:rs1061170 and CFH:rs800292 (Pcorrected = 0.03).
|
27149696 |
2016 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Odds ratios, especially for the main risk polymorphisms in ARMS2 (rs10490924) and CFH (rs1061170), gained with increasing disease severity and bilateralism (exemplarily: rs1061170: unilateral early AMD: OR = 1.18; bilateral early AMD: OR = 1.20; unilateral intermediate AMD: OR = 1.28; bilateral intermediate AMD: OR = 1.39, unilateral geographic atrophy (GA): OR = 1.50; bilateral GA: OR = 1.71).
|
27257685 |
2016 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Considering GA and CNV separately showed that the effect of CFH:rs10737680 was stronger for progression to CNV.
|
27832277 |
2016 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In fact, we demonstrate that gene variants of CFH and CFB, as well as demographic risk factors, confer significant risk for GA progression (both rate of progression and relative growth) within a Spanish population.
|
24557084 |
2014 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Early AMD lesion characteristics were assessed for association with GA incidence using eye-specific data and generalized estimating equation models adjusting for age, current smoking, and presence of risk alleles of the complement factor H (CFH) or age-related maculopathy susceptibility 2 (ARMS2) genes, genotyped or imputed using genome-wide scan data.
|
23706948 |
2013 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although genetic markers were associated significantly with 3-year CNV (CFH: Y402H; ARMS2: A69S) and GA incidence (CFH: Y402H), the inclusion of genetic factors in the models provided only marginal improvements in predictive performance.
|
22704140 |
2012 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
|
Geographic Atrophy
|
0.200 |
Biomarker
|
disease |
BEFREE |
CFH confers more risk to the bilaterality of geographic atrophy, whereas HTRA1/LOC387715 contributes more to the bilaterality of choroidal neovascularization.
|
21402993 |
2011 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Growth rates of GA calculated from digitized serial fundus photographs showed no association with variants in the CFH, C2, C3, APOE, or TLR3 genes.
|
20381870 |
2010 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study confirms that variants at CFH, C3, and ARMS2 confer significant risks for GA due to AMD.
|
19823576 |
2009 |
|
Geographic Atrophy
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our studies however show that both the HTRA1 and LOC387715/ARMS2 SNP appear to contribute equally to disease risk (both geographic atrophy and choroidal neovascularization) with no evidence of interaction with CFH.
|
18682806 |
2008 |
|
Geographic Atrophy
|
0.200 |
Biomarker
|
disease |
BEFREE |
Association analysis of CFH polymorphisms suggest that CFH may play a role in the development of pigmentary abnormalities and may modify the progression along the PA/GA scale.
|
17591865 |
2007 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The CFH Y402H variant is strongly associated with both GA and CNV in the U.K. population.
|
16431947 |
2006 |
|
Geographic Atrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine if the complement factor H gene (CFH) determines risk for development of geographic atrophy (GA).
|
16828512 |
2006 |