HFE, homeostatic iron regulator, 3077

N. diseases: 415; N. variants: 59
Disease: Coronary Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Meta-analyses of HFE variants in coronary heart disease. 23792061 2013
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Plasma ferritin levels, genetic variations in HFE gene, and coronary heart disease in Chinese: a case-control study. 21696736 2011
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE HFE gene mutations increase the risk of coronary heart disease in women. 20640879 2010
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE The results of this large individual patient data meta-analysis do not support the view that HFE gene mutations are associated with an increased risk of coronary heart disease or acute myocardial infarction. 20031541 2008
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE HFE mutations and risk of coronary heart disease in middle-aged women. 16968463 2006
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE In contrast, a large number of studies have reported no association between HFE mutations and coronary heart disease. 12850485 2004
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Moreover, several studies have suggested that HFE mutations may be involved in several age-related chronic diseases such as Alzheimer's disease (AD) and coronary heart disease, but apparently paradoxically also with longevity. 12714262 2003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE The results do not support a consistent association between HFE mutations or serum iron indicators and the prevalence of coronary heart disease. 12427496 2002
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. 11257277 2001
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Relation of HFE gene mutations, high iron stores and early onset coronary artery disease. 9520858 1998