Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, this analysis provides a neurobiological rationale for a recently completed clinical study in MS patients showing that antibody-mediated neutralization of pHERV-W ENV exerts neuroprotective effects.
|
31213545 |
2019 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activation and involvement of human endogenous retroviruses W family envelope gene (HERV-W env, also called ERVWE1) have been reported in several neuropsychiatric disorders, including schizophrenia, as well as in multiple sclerosis (MS).
|
30397826 |
2019 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, Syncytin-1 activity may represent a novel molecular pathogenic mechanism in neuropyschological diseases, such as schizophrenia and MS.
|
30245643 |
2018 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We developed a peptide nucleic acid (PNA) strand invasion technique for the differentiation between multiple sclerosis-associated retrovirus (MSRV) and ERVWE1 sequences, both molecularly similar, belonging to the human endogenous retrovirus HERV-W family.
|
29313202 |
2018 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two human endogenous retroviruses of the HERV-W family are proposed as multiple sclerosis (MS) co-factors: MS-associated retrovirus (MSRV) and ERVWE1, whose env proteins showed several potentially neuropathogenic features, in vitro and in animal models.
|
29307292 |
2018 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased circulating levels of Abs directed against the HERV-W env-su<sub>93-108</sub> and HERV-W env-su<sub>248-262</sub> peptide fragments could serve as possible biomarkers in patients with MS.
|
29603839 |
2018 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mimicry between syncytin-1, a HERV-W envelope protein that is expressed during placentation, and myelin proteins may also explain the higher prevalence of multiple sclerosis in women.
|
28189601 |
2017 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of multiple sclerosis-associated retrovirus (MSRV)-type DNA of Env gene was measured in peripheral blood mononuclear cells from 52 patients with relapsing-remitting multiple sclerosis (RRMS) and 40 healthy controls using specific quantitative PCR (qPCR) analysis.
|
28165135 |
2017 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A peptide nucleic acid (PNA)-mediated technique for the discrimination between multiple sclerosis-associated retrovirus and ERVWE1 sequence has been developed.
|
27921323 |
2017 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study is to verify whether HIV activates two endogenous retroviruses of the human endogenous retrovirus (HERV)-W family, multiple sclerosis-associated retrovirus (MSRV) and Syncytin-1, whose neuropathogenic and immunopathogenic properties could contribute to HIV-related neurodegeneration.
|
25250834 |
2014 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quantitative RT-PCR likewise did not reveal differences in MS regarding HERV-W env general transcript or ERVWE1- and ERVWE2-specific transcript levels.
|
24109235 |
2013 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular characteristics of HERV-W env also differ from what was observed in Multiple Sclerosis (MS) and may represent distinct features of the genome of patients with BD and SZ.
|
23212585 |
2012 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In search of links, the expression of HERV-W/MSRV/syncytin-1, with/without exposure to EBV or to EBV glycoprotein350 (EBVgp350), was studied on peripheral blood mononuclear cells (PBMC) from healthy volunteers and MS patients, and on astrocytes, by discriminatory env-specific RT-PCR assays, and by flow cytometry.
|
23028727 |
2012 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The HERV-W envelope-encoded glycosylated protein, syncytin-1, is encoded by chromosome 7q21 and exhibits increased glial expression within MS lesions.
|
20696240 |
2011 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By mapping HERV-W env cDNA sequences (n = 332) from peripheral blood mononuclear cells of patients with MS and healthy controls onto individual genomic HERV-W env elements, we identified seven transcribed HERV-W env loci in these cells, including ERVWE1.
|
19368703 |
2009 |
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The data of MS patients and controls indicated that MSRV and ERVWE1 are both expressed in the brain of MS patients, while only MSRV is present in the blood; MSRV was released in culture by PBMCs of MSRV-producer individuals.
|
19505508 |
2009 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our analyses reveal that ERVWE1 env-encoding DNA and RNA exhibited increased detection (p < 0.05) and expression (p < 0.01) in the brains of MS patients.
|
17961112 |
2007 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using transient transfection assays, we observed that the MS-detrimental cytokines TNFalpha, interferon-gamma, interleukin-6, and interleukin-1 activate the ERVWE1 promoter, while the MS-protective interferon-beta is inhibitory.
|
17258784 |
2007 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations emphasize the selective induction of syncytin-1 in brain tissue of MS patients but also illustrate the complex dynamics of this retroelement in neuroinflammatory processes.
|
17209768 |
2006 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Syncytin-mediated neuroinflammation and death of oligodendrocytes, with the ensuing neurobehavioral deficits, were prevented by the antioxidant ferulic acid in a mouse model of multiple sclerosis.
|
15452578 |
2004 |