|
Vibratory urticaria
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
This includes the Mas-related G protein-coupled receptor X2, which might contribute to reactions to diverse antimicrobials and polybasic compounds, and the adhesion G protein-coupled receptor E2, variants of which are associated with familial vibratory urticaria and are activated by mechanical vibration.
|
29454835 |
2018 |
|
Vibratory urticaria
|
0.620 |
GeneticVariation
|
disease |
BEFREE |
We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid position 492 (p.C492Y), as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds.
|
26841242 |
2016 |
|
Vibratory urticaria
|
0.620 |
GermlineCausalMutation
|
disease |
ORPHANET |
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
|
26841242 |
2016 |
|
Vibratory urticaria
|
0.620 |
GeneticVariation
|
disease |
UNIPROT |
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
|
26841242 |
2016 |
|
Vibratory urticaria
|
0.620 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
DERMODISTORTIVE URTICARIA
|
0.500 |
GermlineCausalMutation
|
disease |
ORPHANET |
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
|
26841242 |
2016 |
|
DERMODISTORTIVE URTICARIA
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Vibratory angioedema
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
|
26841242 |
2016 |
|
Familial dermographism
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our previous study suggested that the overexpression of CD97 in cervical cancer was correlated with the aggressiveness of the tumour and that CD97 might be an independent poor prognostic factor for cervical cancer patients.
|
30883974 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In accordance, overexpression of CD97 promotes trophoblast cell invasion.
|
30791863 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate that two homologous aGPCRs, CD97 and EMR2, modulate angiogenesis and HUVEC proliferation, migration, and invasion through N-cadherin-regulated MMP-9 expression by RGD-independent and -dependent mechanisms, respectively.
|
31594642 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
As a result, decreased ability of migration and invasion was found in CD97 small isoform RNAi cells, which showed, however, no change in cell proliferation.
|
30883974 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma.
|
29704239 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings support targeted blockade of tumor CD97 as an approach to ameliorate metastatic spread.
|
29669286 |
2018 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Functionally, CD97 promoted cell migration and invasion in vitro.
|
29704239 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
E2F2 and EMR2 are preferentially expressed in adenocarcinomas subtypes versus other tumour types (squamous and others).
|
29072692 |
2017 |
|
Androstenedione measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
|
28429243 |
2017 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The PHF21B gene is associated with major depression and modulates the stress response.
|
27777418 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, CD97 and CD55 expressions and biliary soluble CD97 levels were significantly associated with histological grade (p = 0.004, 0.002, and 0.012, respectively), lymph node metastases (p = 0.020, 0.038, and 0.001, respectively), and venous invasion (p = 0.003, 0.002, and 0.001, respectively).
|
28345461 |
2017 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion.
|
27641734 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The markers significantly overexpressed already in earlier tumor stages (pT1-2) of both histological subtypes (n = 19) have been clustered in a "diagnostic signature": PLA2G7, PRAME, MMP1, MMP3, MMP12, LIlRB2, TREM2, CHST2, IGFBP2, IGFBP7, KCNJ8, EMILIN2, CTHRC1, EMR2, WDR72, LPCAT1, COL4A2, CCL4, and SNX10.
|
26631031 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In vitro, exosomes or conditioned medium from the SGC-L cells enhanced cell proliferation (20 % increase) and invasion (30 % increase) as compared with that from SGC-L/CD97-kd cells (p < 0.01).
|
26233326 |
2016 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Gene expression data relating to the invasion-associated proteins ITGA5 (integrin α5), CD97, and ANXA1 (annexin A1) showed prognostic significance in independent GBM cohorts.
|
25853691 |
2015 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Given its proven roles in tumor invasion, expression among aggressive genetic subtypes of GBM, and association with overall survival, CD97 is an attractive therapeutic target for patients with GBM.
|
25714433 |
2015 |