Ventricular arrhythmia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Eight weeks after treatment, electrophysiological properties including heart rate variability (HRV), monophasic action potential duration (MAPD), effective refractory period (ERP) and the inducibility of ventricular arrhythmias and the expression of arrhythmia-related ion channel proteins including Kv4.2, Kv4.3, KChIP2 and Kir2.1 at the IBZ of the left ventricle were examined.
|
30100240 |
2018 |
Ventricular arrhythmia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and sudden cardiac death.
|
27736193 |
2017 |
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of Kv4.2, Kv4.3, KChIP2 and Kir2.1 proteins were significantly decreased in MI group and Ad group.
|
30100240 |
2018 |
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This identifies the KChIP2/miR-34 axis as a central regulator in developing electrical dysfunction and reveals miR-34 as a therapeutic target for treating arrhythmogenesis in heart disease.
|
28263709 |
2017 |
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study is the first to show that K<sup>+</sup> channel modulatory subunits KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they form a channel complex with the K<sup>+</sup> channel pore-forming subunit Kv4.3 in a subset of nociceptors to selectively inhibit mechanical hypersensitivity, a major symptom of neuropathic pain.
|
28330877 |
2017 |
Chronic Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Electronegative LDL may underlie downregulation of KChIP2 in CKD.
|
28094801 |
2017 |
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
One gene regulated by H3K4me3 was Kv channel-interacting protein 2 (Kcnip2), which regulates a cardiac repolarization current that is downregulated in heart failure and functions in arrhythmogenesis.
|
21646717 |
2011 |
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
One gene regulated by H3K4me3 was Kv channel-interacting protein 2 (Kcnip2), which regulates a cardiac repolarization current that is downregulated in heart failure and functions in arrhythmogenesis.
|
21646717 |
2011 |
Atrial Fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced L-type Ca(2+) channel, RyR2, SERCA2, Kv1.5, and KChIP2 expression and borderline increased HCN2 expression were observed in the patients with AF and mitral valvular heart disease.
|
21179275 |
2010 |
Heart valve disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Reduced L-type Ca(2+) channel, RyR2, SERCA2, Kv1.5, and KChIP2 expression and borderline increased HCN2 expression were observed in the patients with AF and mitral valvular heart disease.
|
21179275 |
2010 |
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These studies demonstrate that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to arrhythmias, establishing a novel genetic pathway for ventricular tachycardia via a loss of the transmural gradient of I(to).
|
11747815 |
2001 |
Tachycardia, Ventricular
|
0.010 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to arrhythmias, establishing a novel genetic pathway for ventricular tachycardia via a loss of the transmural gradient of I(to).
|
11747815 |
2001 |