Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia
0.020 AlteredExpression disease BEFREE Eight weeks after treatment, electrophysiological properties including heart rate variability (HRV), monophasic action potential duration (MAPD), effective refractory period (ERP) and the inducibility of ventricular arrhythmias and the expression of arrhythmia-related ion channel proteins including Kv4.2, Kv4.3, KChIP2 and Kir2.1 at the IBZ of the left ventricle were examined. 30100240 2018
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia
0.020 Biomarker disease BEFREE Potassium Channel Interacting Protein 2 (KChIP2) is suggested to be responsible for the circadian rhythm in repolarization duration, ventricular arrhythmias, and sudden cardiac death. 27736193 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 AlteredExpression disease BEFREE The expression levels of Kv4.2, Kv4.3, KChIP2 and Kir2.1 proteins were significantly decreased in MI group and Ad group. 30100240 2018
CUI: C0018799
Disease: Heart Diseases
Heart Diseases
0.010 Biomarker group BEFREE This identifies the KChIP2/miR-34 axis as a central regulator in developing electrical dysfunction and reveals miR-34 as a therapeutic target for treating arrhythmogenesis in heart disease. 28263709 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia
0.010 Biomarker phenotype BEFREE This study is the first to show that K<sup>+</sup> channel modulatory subunits KChIP1, KChIP2, and DPP10 are potential drug targets for neuropathic pain because they form a channel complex with the K<sup>+</sup> channel pore-forming subunit Kv4.3 in a subset of nociceptors to selectively inhibit mechanical hypersensitivity, a major symptom of neuropathic pain. 28330877 2017
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 AlteredExpression group BEFREE Electronegative LDL may underlie downregulation of KChIP2 in CKD. 28094801 2017
CUI: C0018801
Disease: Heart failure
Heart failure
0.010 AlteredExpression disease BEFREE One gene regulated by H3K4me3 was Kv channel-interacting protein 2 (Kcnip2), which regulates a cardiac repolarization current that is downregulated in heart failure and functions in arrhythmogenesis. 21646717 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.010 AlteredExpression disease BEFREE One gene regulated by H3K4me3 was Kv channel-interacting protein 2 (Kcnip2), which regulates a cardiac repolarization current that is downregulated in heart failure and functions in arrhythmogenesis. 21646717 2011
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 AlteredExpression disease BEFREE Reduced L-type Ca(2+) channel, RyR2, SERCA2, Kv1.5, and KChIP2 expression and borderline increased HCN2 expression were observed in the patients with AF and mitral valvular heart disease. 21179275 2010
CUI: C0018824
Disease: Heart valve disease
Heart valve disease
0.010 AlteredExpression group BEFREE Reduced L-type Ca(2+) channel, RyR2, SERCA2, Kv1.5, and KChIP2 expression and borderline increased HCN2 expression were observed in the patients with AF and mitral valvular heart disease. 21179275 2010
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia
0.010 Biomarker phenotype BEFREE These studies demonstrate that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to arrhythmias, establishing a novel genetic pathway for ventricular tachycardia via a loss of the transmural gradient of I(to). 11747815 2001
CUI: C0042514
Disease: Tachycardia, Ventricular
Tachycardia, Ventricular
0.010 Biomarker disease BEFREE These studies demonstrate that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to arrhythmias, establishing a novel genetic pathway for ventricular tachycardia via a loss of the transmural gradient of I(to). 11747815 2001