Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study demonstrated that high cyclin E and HGF expression is closely correlated with tumor size, tumor differentiation degree, and TNM stage in patients with ESCC.
|
31533461 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Comparison of VEGF, EGF, and HGF in tumour and non-tumorous tissues showed no significant differences and no correlations with tumour stage.
|
29926253 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A cytotoxicity study against human oral squamous cell carcinoma cell lines (Ca9-22, HSC-2, and HSC-4) and human mesenchymal normal oral cells (HGF, HPC, and HPLF) showed cytotoxic effects with tumor-specificity higher than 5.2, 3.0, 1.6, and 2.0 for compounds <b>5</b>, <b>2</b>, <b>9</b>, and <b>3</b>, respectively.
|
31532650 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Positron emission tomography using HiP-8 as a radiotracer enabled noninvasive visualization and simultaneous inhibition of HGF-MET activation status in tumors in a mouse model.
|
31101918 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since HGF treatment drives monocytes toward the M2 phenotype and NLCs exhibit features of tumor associated macrophages of type 2 we suggested that HGF, released either by cells of the microenvironment or leukemic cells, exerts a double effect: i) enhances CLL cells survival and ii) drives differentiation of monocytes-macrophages to an oriented immune suppressive phenotype.
|
30642077 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analyzed tumor ILK, β-receptor subunit glycoprotein 130 (gp130), SHP2, and stromal hepatocyte growth factor (HGF) and interleukin-6 (IL-6) mRNA expression in baseline tumor specimens of advanced EGFR-mutation positive NSCLC patients treated with EGFR TKIs.
|
30473379 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among those, the hepatocyte growth factor/MET (HGF/MET) axis is emerging as a critical player not only in the tumor itself but also in the immune microenvironment in which the tumor grows and advances in its development.
|
31476283 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The association between HGF and miR‑200a was associated with the degree of tumor malignancy and cell migration and invasion. miR‑200a negatively regulated HGF expression by targeting the 3'‑untranslated region of the HGF mRNA. miR‑200a overexpression induced HGF downregulation, decreased NSCLC cell migration and invasion, promoted apoptosis, and decreased cell survival in A549 and H1299 cells in response to ionizing radiation.
|
30569179 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Other biomarkers such as circulating tumor DNA (ctDNA) and tumor HGF levels have also been briefly covered.
|
31512514 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The system of hepatocyte growth factor (HGF) and its receptor c-Met plays a critical role in tumor invasive growth and metastasis.
|
30897285 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, when the tumor lines were tested at HGF levels typically detected in human serum (0.4 to 0.8 ng/mL), inhibitor activity was lost.
|
30719213 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hepatocyte growth factor (HGF) and its receptor MET are expressed in the salivary glands during developmental stages and tumor formation; however, the function of HGF in injured salivary gland tissues remains unclear.
|
31136962 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
With the goal to investigate the molecular basis of MET amplification (MET<sup>amp</sup>) and hepatocyte growth factor (HGF) autocrine-driven tumors in response to MET tyrosine kinase inhibitors (TKI) and neutralizing antibodies, we compared cancer cells harboring MET<sup>amp</sup> (MKN45 and MHCCH97H) or HGF-autocrine (JHH5 and U87) for their sensitivity and downstream biological responses to a MET-TKI (INC280) and an anti-MET monoclonal antibody (MetMab) in vitro, and for tumor inhibition in vivo.
|
30208970 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carcinoma-associated fibroblasts (CAFs) are dominant components of the tumor microenvironment (TME) that promote the development, progression and metastasis of cancer. c-Met is a receptor of the hepatocyte growth factor (HGF), which is involved in lymphangiogenesis.
|
29375714 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CRZ treatment had no adverse effect on hearing; however, it did not affect tumor-induced hearing loss, presumably because cMET blockade did not change tumor hepatocyte growth factor (HGF) levels.
|
29440379 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
At the 1st, 2nd, 3rd and 4th week time point, tumor volume in group A < group B < group C, and the difference has statistical significance (all <i>p</i><0.001).The relative mRNA and protein levels of bFGF, TGFβ-1 and HGF were significantly higher in group B and C compared with group A (all <i>p</i><0.05), as well as the mRNA levels of bFGF, HGF were higher in group C than group B (<i>p</i><0.05), and the protein levels of bFGF, TGFβ-1 were higher in group C than group B (<i>p</i><0.05).
|
29989060 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.
|
30401749 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer.
|
29285843 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The hepatocyte growth factor (HGF) produced by tumor and stromal cells acts as a multifunctional cytokine and activates the c-MET receptor, which is expressed in different tumor cell types.
|
30352967 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model.
|
29203124 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Baseline angioprotein-1 and hepatocyte growth factor showed a direct correlation with tumor volume whereas changes in vascular cell adhesion molecule 1 showed significant correlations with 18F-fluorothymidine (FLT) positron emission tomography (PET).
|
29398577 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, dysregulated HGF/c-Met signalling is a driving factor for numerous malignancies and promotes tumour growth, invasion, dissemination and/or angiogenesis.
|
29157685 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our study found that the increased expression of HGF in CAFs induced by MET-unamplified GC contributed to the malignant phenotype of both MET-unamplified GC and CAFs in tumor microenvironment.
|
30158543 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MCC knockdown disrupted cell-cell adhesive strength and integrity in the dispase and transepithelial electrical resistance assays, enhanced hepatocyte growth factor-induced cell scatter and increased tumour cell invasiveness in an organotypic assay.
|
29035389 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry for VEGFR-2, MET, and HGF expression and next-generation sequencing of tumor tissue were performed and correlated with outcome.
|
29445030 |
2018 |