HGF, hepatocyte growth factor, 3082

N. diseases: 671; N. variants: 22
Disease: Childhood Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Thus, our study proved that paeoniflorin could inhibit migration and invasion and actin cytoskeleton rearrangement through inhibition of HGF/c-Met/RhoA/ROCK signaling in glioblastoma, suggesting that paeoniflorin might be a candidate compound to treat glioblastoma. 30886866 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE H1/pHGFK1 nanoparticles are a potential radiosensitiser and angiogenic inhibitor for glioblastoma treatment. 29348487 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE We also demonstrated that the MET-AXL-ELMO2-DOCK180 complex is critical for HGF-induced cell migration and invasion in glioblastoma or other cancer cells. 30108175 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE However, all glioblastoma lines expressed mRNA for HGF activator (HGFAC), a target protease of HAI-2/SPINT2. 29987920 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Importantly, immunohistochemical analyses of human glioblastoma and ex vivo single-cell gene expression profiling of TGF-β and HGF confirm the negative interaction between both pathways. 29238047 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma. 28696366 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. 26381735 2015
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Furthermore, Gab1 is required for HGF-induced Dock7 and Rac1 activation and glioblastoma cell invasion. 24518591 2014
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Regulation of HGF expression by ΔEGFR-mediated c-Met activation in glioblastoma cells. 23359207 2013
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Thus, HGF autocrine glioblastoma bears an activated MET signaling pathway that may predict sensitivity to MET inhibitors. 22203985 2012
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE We also observed that RhoG is activated by both HGF and EGF, two factors that are thought to be clinically relevant drivers of glioblastoma invasive behavior, and that RhoG is overexpressed in human glioblastoma tumors versus non-neoplastic brain. 22966858 2012
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE HGF/SF and menthol increase human glioblastoma cell calcium and migration. 18485891 2008
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Hypoxia sensitized glioblastoma cell lines which showed hypoxic induction of c-Met to the motogenic effects of SF/HGF. 17372907 2007
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription. 11909963 2002
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE In the present study SF/HGF is shown to induce the expression of c-met in two human glioblastoma cell lines, U-373 MG and T98G, and the signaling pathways involved in this induction are dissected. 11238734 2001
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE We detected strong SF/HGF expression by the majority of the tumor cells and by vascular endothelial cells in all glioblastoma specimens analyzed. 11296484 2001
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Anti-c-met U1/ribozyme gene transfer inhibited the ability of SF/HGF to protect against single-strand DNA breakage, DNA fragmentation, and glioblastoma cell death caused by DNA-damaging agents, demonstrating a requirement for c-met receptor function. 10945642 2000
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of solid tumors including glioblastoma. 10873600 2000
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 Biomarker disease BEFREE Since glioblastomas frequently co-express HGF/SF and its receptor, our results suggest that HGF/SF might contribute to the invasiveness of glioblastoma cells through autocrine induction of MMP-2 expression and activation. 10389763 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE Inhibition of SF/HGF or c-met expression in glioblastoma cells possessing an SF/HGF-c-met autocrine loop reduced tumor cell clonogenicity (P =.005 for SF/HGF and P=.009 for c-met) and substantially inhibited tumorigenicity (P<.0001) and tumor growth in vivo (P<.0001). 10491431 1999
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.100 AlteredExpression disease BEFREE The concomitant expression of HGF, HGF activator and c-met was also detected in one glioblastoma case in vivo out of five tested. 7556648 1995