|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Studies carried out in primary APL cells and in a cell line model of APL with inducible PML-RARα expression directly support the view that this fusion protein through HHEX downmodulation stimulates the expression of various genes involved in angiogenesis and inhibits cell differentiation.
|
27052408 |
2016 |
|
Acute Undifferentiated Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conditional knockout models of murine acute myeloid leukemia indicate that <i>Hhex</i> maintains leukemia stem cell self-renewal by enabling Polycomb-mediated epigenetic repression of the Cdkn2a tumor suppressor locus, encoding p16<sup>Ink4a</sup> and p19<sup>Arf</sup> However, whether <i>Hhex</i> overexpression also affects hematopoietic differentiation is unknown.
|
29453249 |
2018 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found markers of chronic alcohol consumption (HEX A), alcohol dependence (FUC and MAN) and chronic alcohol consumption and dependence (GLU).
|
28660791 |
2019 |
|
Alzheimer Disease, Late Onset
|
0.020 |
Biomarker
|
disease |
BEFREE |
One series (MCR, 188 age-matched case-control pairs) did not show association (p=0.64) with the six haplotypes in the 276-kb region spanning three genes (IDE, KNSL1, and HHEX) previously shown to associate with LOAD.
|
15024728 |
2004 |
|
Alzheimer Disease, Late Onset
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic linkage and association studies in late-onset Alzheimer's disease (LOAD) or its endophenotypes have pointed to several regions on chromosome 10q, among these the ∼ 250 kb linkage disequilibrium (LD) block harboring the genes IDE, KIF1, and HHEX.
|
20724036 |
2012 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.
|
23036584 |
2013 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes.
|
26173052 |
2015 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that alterations in the transcription factors PAX-8, TTF-1 and HEX gene expression, by acting individually or together, have a role in both thyroidal tumorigenesis and in the dedifferentiation process.
|
16584511 |
2006 |
|
Benign Prostatic Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that PRH and hyper-phosphorylated PRH are present in normal prostate epithelial cells, and that hyper-phosphorylated PRH levels are elevated in benign prostatic hyperplasia, prostatic adenocarcinoma, and prostate cancer cell lines.
|
28134934 |
2017 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Aim of the present study was to evaluate the localization and the function of the protein HEX in normal and tumoral breast tissues and in breast cancer cell lines.
|
16854221 |
2006 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
HEX expression and nuclear localization were investigated by immunohistochemistry in normal and cancerous breast tissue, as well as in breast cancer cell lines.
|
16854221 |
2006 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor and oncogenic activity in different disease contexts; however, the role of PRH in breast cancer is poorly understood.
|
28604763 |
2017 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Six SNPs were associated with all-cause (CDKAL1-rs981042, P = 0.0032; HHEX-rs1111875, P = 0.0361; and INSR-rs919275, P = 0.0488) or BC-specific (CDKN2A/CDKN2B-rs3218020, P = 0.0225; CDKAL1-rs981042, P = 0.0246; and TCF2/HNF1B-rs3094508, P = 0.0344) mortality in additive genotype models, at α = 0.05.
|
30457165 |
2019 |
|
Carbohydrate intolerance
|
0.010 |
Biomarker
|
disease |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Since modification of localization occurs during lactation and tumorigenesis, we suggest that HEX may play a role in differentiation of the epithelial breast cell.
|
16854221 |
2006 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
These findings suggest that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis.
|
11889211 |
2002 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Interestingly, HEX gene expression was significantly decreased in both hyper- and hypofunctioning benign tissues and also in carcinomas.
|
16584511 |
2006 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
HEX mRNA was detected by RT-PCR either in normal tissues or in thyroid adenomas and differentiated (papillary and follicular) carcinomas.
|
11889211 |
2002 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
For example, RRM2, a ribonucleotide reductase involved in DNA synthesis, was upregulated 32-fold in IDC-associated blood vessels; ATF1, a nuclear activating transcription factor involved in cellular growth and survival was upregulated 23-fold in IDC-associated blood vessels and HEX-B, a hexosaminidase involved in the breakdown of GM2 gangliosides, was upregulated 8-fold in IDC-associated blood vessels.
|
23056178 |
2012 |
|
Cholangiocarcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423).
|
27105501 |
2016 |
|
Cholelithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The MC4R(rs17782313) (OR 1.27, 95% CI [1.02;1.58]), MAP2K5(rs2241423) (OR 1.80, 95% CI [1.04;3.41]), NRXN3(rs10146997) (OR 1.26, 95% CI [1.01;1.57]), HHEX(rs1111875) (OR 1.29, 95% CI [1.03;1.62]), FAIM2(rs7138803) (OR 0.66, 95% CI [0.48;0.91]), and apolipoprotein E4 allele (OR 0.76, 95% CI [0.59;0.98]) were associated with gallstone disease.
|
28799434 |
2017 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
PRH/HHEX expression was elevated in CCA and depletion of PRH reduced CCA tumour growth in a xenograft model.
|
31843982 |
2020 |
|
Congenital glucose-galactose malabsorption
|
0.010 |
Biomarker
|
disease |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Congenital heart disease
|
0.010 |
Biomarker
|
group |
BEFREE |
The HHEX gene is not related to congenital heart disease in 296 Chinese patients.
|
23929257 |
2013 |