|
Congenital Hypothyroidism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NKX2.1, NKX2.5, FOXE1 and HHEX genes were directly sequenced in patients with syndromic CH.
|
17468187 |
2007 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal.
|
23104008 |
2012 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first study to examine the HHEX gene in non-symptomatic CHD cases, and this has expanded our knowledge about its etiology.
|
23929257 |
2013 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes.
|
26173052 |
2015 |
|
Diabetes
|
0.080 |
Biomarker
|
disease |
BEFREE |
Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8.
|
21198374 |
2011 |
|
Diabetes
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our data show that SNPs near IGFBP2, CDKAL1, SLC30A8, CDKN2B, HHEX and FTO are also associated with diabetes in non-selected patients with type 2 diabetes.
|
18437351 |
2008 |
|
Diabetes
|
0.080 |
Biomarker
|
disease |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Diabetes
|
0.080 |
Biomarker
|
disease |
BEFREE |
Although the association was stronger in female subjects (OR, 4.46; 95% CI, 1.15-17.3, p = 0.0304) among healthy individuals (N = 2461), the association between HHEX and diabetes was much stronger in male heavy smokers (OR, 4.03; 95% CI, 1.19-13.6, p = 0.0247) than in nonsmokers (p = 0.9709) and ex-smokers (p = 0.2399).
|
29720110 |
2018 |
|
Diabetes
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable.
|
20616309 |
2010 |
|
Diabetes
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We aimed to characterise the possible longitudinal associations of common diabetes-susceptibility variants in the KCNJ11, PPARG, TCF7L2, IGF2BP2, CDKAL1, SLC30A8 and HHEX gene loci, with fasting glucose level; and of an obesity-associated variant in the FTO gene, with body mass index (BMI).
|
20929593 |
2010 |
|
Diabetes
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk.
|
23166797 |
2012 |
|
Diabetes
|
0.080 |
Biomarker
|
disease |
BEFREE |
There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes.
|
26173052 |
2015 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Our data show that SNPs near IGFBP2, CDKAL1, SLC30A8, CDKN2B, HHEX and FTO are also associated with diabetes in non-selected patients with type 2 diabetes.
|
18437351 |
2008 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8.
|
21198374 |
2011 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk.
|
23166797 |
2012 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes.
|
26173052 |
2015 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable.
|
20616309 |
2010 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Although the association was stronger in female subjects (OR, 4.46; 95% CI, 1.15-17.3, p = 0.0304) among healthy individuals (N = 2461), the association between HHEX and diabetes was much stronger in male heavy smokers (OR, 4.03; 95% CI, 1.19-13.6, p = 0.0247) than in nonsmokers (p = 0.9709) and ex-smokers (p = 0.2399).
|
29720110 |
2018 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We aimed to characterise the possible longitudinal associations of common diabetes-susceptibility variants in the KCNJ11, PPARG, TCF7L2, IGF2BP2, CDKAL1, SLC30A8 and HHEX gene loci, with fasting glucose level; and of an obesity-associated variant in the FTO gene, with body mass index (BMI).
|
20929593 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Only PPARG and HHEX-IDE showed any evidence of association with type 1 diabetes cases and controls (p = 0.004 and p = 0.003, respectively; p > 0.05 for other SNPs).
|
19455305 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The association of low birth weight and type 2 diabetes risk alleles of the HHEX-IDE locus is confirmed in children of mothers with type 1 diabetes.
|
19622614 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
|
17928989 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We validated the association of polymorphisms of the HHEX gene with T2DM in the MESYBEPO cohort.
|
19117022 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.
|
17971426 |
2008 |