|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Although the association was stronger in female subjects (OR, 4.46; 95% CI, 1.15-17.3, p = 0.0304) among healthy individuals (N = 2461), the association between HHEX and diabetes was much stronger in male heavy smokers (OR, 4.03; 95% CI, 1.19-13.6, p = 0.0247) than in nonsmokers (p = 0.9709) and ex-smokers (p = 0.2399).
|
29720110 |
2018 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
HHEX and PROX1 play significant roles in carbohydrate intolerance and diabetes because these transcription factors may be involved in the regulation of insulin secretion and in glucose and lipid metabolism.
|
27684496 |
2017 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
There was a significant interaction between HHEX_23-AA and diabetes on dementia (HR 4.79, 95% CI 1.63-8.90, p = 0.013) and AD (HR 3.55, 95% CI 1.45-9.91, p = 0.025) compared to the GG genotype without diabetes.
|
26173052 |
2015 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk.
|
23166797 |
2012 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Worldwide researchers have invested time, effort, and money during the last years to find new genes associated with diabetes susceptibility, such as LOC387761, HHEX, EXT2, and SLC30A8.
|
21198374 |
2011 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
In contrast, variants near insulin-like growth factor-binding protein 2 (IGFBP2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), solute carreir family 30 (zinc transporter), member 8 (SLC30A8), hematopoietically-expressed homeobox (HHEX), and transcription factor 7-like2 (TCF7L2) were clearly associated with diabetes; no evidence for an association to CAC was observable.
|
20616309 |
2010 |
|
Diabetes Mellitus
|
0.080 |
GeneticVariation
|
group |
BEFREE |
We aimed to characterise the possible longitudinal associations of common diabetes-susceptibility variants in the KCNJ11, PPARG, TCF7L2, IGF2BP2, CDKAL1, SLC30A8 and HHEX gene loci, with fasting glucose level; and of an obesity-associated variant in the FTO gene, with body mass index (BMI).
|
20929593 |
2010 |
|
Diabetes Mellitus
|
0.080 |
Biomarker
|
group |
BEFREE |
Our data show that SNPs near IGFBP2, CDKAL1, SLC30A8, CDKN2B, HHEX and FTO are also associated with diabetes in non-selected patients with type 2 diabetes.
|
18437351 |
2008 |