HHEX, hematopoietically expressed homeobox, 3087

N. diseases: 73; N. variants: 2
Disease: Leukemia, Myelocytic, Acute ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 Biomarker disease BEFREE HHEX could replace RUNX1 in cooperating with FLT3-ITD to induce AML. 28213513 2017
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 AlteredExpression disease BEFREE Here we found that the hematopoietically expressed homeobox gene Hhex is overexpressed in acute myeloid leukemia (AML) and is essential for the initiation and propagation of MLL-ENL-induced AML but dispensable for normal myelopoiesis, indicating a specific requirement for Hhex for leukemic growth. 26728554 2016
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 AlteredExpression disease LHGDN Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia. 18388181 2008