HHEX, hematopoietically expressed homeobox, 3087

N. diseases: 73; N. variants: 2
Disease: Impaired insulin secretion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 GeneticVariation disease BEFREE Importantly, variations within the HHEX gene conferred the impaired insulin secretion and changes of insulin degradation but no alteration in insulin sensitivity in carriers of risk alleles. 19117022 2009
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 GeneticVariation disease BEFREE However, both aspects of beta cell function are not necessarily linked, as impaired insulin secretion is specifically present in variants of HHEX and impaired proinsulin conversion is specifically present in a variant of SLC30A8. 18264689 2008