HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Disease: Acquired Immunodeficiency Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		0.010 Biomarker group BEFREE Overall, this study demonstrates that HIF-1α plays a crucial role in HIV-1 pathogenesis by promoting viral replication and the release of EVs that orchestrate lymphocyte- and macrophage-mediated inflammatory responses.<b>IMPORTANCE</b> Human immunodeficiency virus type 1 (HIV-1) is a very important global pathogen that preferentially targets CD4<sup>+</sup> T cells and causes acquired immunodeficiency syndrome (AIDS) if left untreated. 30206166 2018