|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.
|
18844219 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
These data suggest that hypoxia enhances the expression of MUC1 through the transcriptional regulation by HIF-1alpha in a human lung epithelial cell line.
|
19141292 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Chromatin immunoprecipitation identified a previously unappreciated binding site for the hypoxia inducible factor-1 (HIF-1), and promoter studies established its relevance by loss of repression following point mutation.
|
18779379 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
We suggest a dual role for HIF-1alpha in providing a survival or death signal, based on hypoxia duration, and consider the nuclear transcription factor, CREB, to be a possible target for hypoxic therapy against leukemia disease.
|
18996491 |
2009 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Herein, we identify a mechanism of increased LT in SCD and show HIF-1alpha as a hypoxia-independent target of PlGF.
|
18945963 |
2009 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These observations demonstrate that MGr1-Ag/37LRP is actively engaged by hypoxia and represent a novel HIF-1 target.
|
19123465 |
2009 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Endogenous hypoxia markers: case not proven!
|
18290322 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Thioredoxin-interacting protein, a putative tumor suppressor gene, is induced in response to hypoxia in a HIF-1alpha-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy.
|
18376310 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid kinase balancing the intracellular level of key signaling sphingolipids, modulates the transcription factor hypoxia inducible factor 1alpha (HIF-1alpha), master regulator of hypoxia.
|
18922940 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These results provide evidence of a key signalling pathway involving HIF-1alpha and TWIST that promotes metastasis in response to intratumoural hypoxia.
|
18297062 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins.
|
18222538 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Chromatin immunoprecipitation assay demonstrated that HIF-1 alpha directly bound to this region under normoxia, and this binding activity was significantly enhanced under hypoxia.
|
18339685 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
In response to hypoxia, HIF-1 bound to this site and transactivated SAG expression.
|
17828303 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These results suggest that the hypoxia induces the migration of CASMCs, and that the migration is elicited by TSP-1 of which induction is fully dependent on the stabilization of HIF-1alpha, in autocrine regulation.
|
18384112 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In this study, we have investigated the potential roles of RORalpha in the hypoxia signaling pathway in connection with activation of HIF-1alpha.
|
18658046 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In conclusion, PCAF regulates the balance between cell-cycle arrest and apoptosis in hypoxia by modulating the activity and protein stability of both p53 and HIF-1alpha.
|
18574470 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen.
|
18354193 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Moreover, repression of AK by ambient hypoxia was abolished in conditional HIF-1alpha mutant mice in vivo.
|
18309031 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
In conclusion, the signals evoked by hypoxia and after EDHB treatment differentially regulate HO-1 mRNA expression through HIF-1alpha-independent mechanisms.
|
18799519 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Thus, hypoxia dictates an anti-inflammatory program by driving expression of HIF-1alpha that acts to increase the number and suppressive properties of naturally occurring CD4(+)CD25(+) Treg.
|
18792019 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
The transcriptional activation of HIF-1 induced by hypoxia or DFO was visualized by both bioluminescence and scintigraphic reporter gene systems.
|
18703592 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
|
18713068 |
2008 |
|
Anoxia
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
These findings indicate that HIF-1alpha is elevated in both TM and GBM, suggesting that although hypoxia is one of the most important and powerful stimuli for HIF-1alpha elevation and consequently angiogenesis, other mechanisms may play roles in HIF-1alpha stimulation in benign brain tumors such as TM.
|
18621534 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Our studies show that PlGF-induced expression of the potent vasoconstrictor ET-1 and its cognate ET-BR receptor occur via activation of HIF-1 alpha, independent of hypoxia.
|
18411415 |
2008 |
|
Anoxia
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Using the luciferase reporter system, HIF-1alpha was shown to transactivate the HGFA promoter under hypoxia.
|
18422749 |
2008 |