|
Liver neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Macrophage-specific hypoxia-inducible factor-1α deletion suppresses the development of liver tumors in high-fat diet-fed obese and diabetic mice.
|
30897274 |
2019 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment.
|
29171040 |
2018 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
We found that T3 treatment increased cellular and secreted FN in human hepatoma cells (HepG2) and human dermal fibroblasts (HF) via the PI3K/Akt/HIF-1 pathway.
|
28974422 |
2017 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Cultured HEP3B cells were exposed to normal oxygen condition, and Cobalt chloride (CoCl2) induced the hypoxic condition, which is an HIF-1 inducer.
|
26299656 |
2016 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Of the ten miRNAs predicted by the 3'-UTR of HIF-1α mRNA, PPIX treatment increased miR-199a-5p, leading to the inhibition of E2F3 expression which is upregulated in mesenchymal liver tumor. miR-199a-5p levels were downregulated in HCC with E2F3 overexpression.
|
25714015 |
2015 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Human hepatoma HepG2 cells were treated with various mitochondrial respiration inhibitors and an uncoupler, respectively, and the mRNA and protein expressions as well as transactivation activity of HIF-1α were determined.
|
23791554 |
2013 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Knockdown of miR-210 increased protein expression of miR-210 targeted genes, but decreased HIF-1α protein in hepatoma xenograft.
|
23618526 |
2013 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
However, conclusions of different studies about the effects of HIF-1alpha expression on hepatoma cell apoptosis remain controversial.
|
23581228 |
2012 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that specific inhibition of HIF-1α expression in combination with radiotherapy would be expected to exert a strong antitumor effect on human hepatoma.
|
21950556 |
2011 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Our results suggest that chaetocin could be developed as an anticancer agent to target HIF-1 in some cancers including hepatoma.
|
21140472 |
2011 |
|
Liver neoplasms
|
0.300 |
Therapeutic
|
group |
RGD |
[Prevention of hepatic tumor growth and metastasis in rats with rapamycin].
|
19335982 |
2009 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
In this study, silibinin was found to inhibit hypoxia-induced HIF-1alpha accumulation and HIF-1 transcriptional activity in human cervical (HeLa) and hepatoma (Hep3B) cells.
|
18978810 |
2009 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
Consistent with these observations, green fluorescent protein-HIF-1 alpha is differently distributed during hypoxia and reoxygenation in hepatoma and endothelial cells.
|
16738327 |
2006 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
In this study, we investigated its effect on hypoxia-inducible factor-1a (HIF-1a) in rat pheochromacytoma (PC12), human osteosarcoma (HOS) and human hepatoma (HepG2) cells.
|
17202857 |
2006 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor 1 alpha and its significance.
|
14672622 |
2004 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
The pro-oxidants H2O2 and buthionine sulfoximine down-regulated HIF-1alpha and P-gp, whereas up-regulation was achieved with the radical scavengers dehydroascorbate, N-acetylcysteine, and vitamin E. The correlation of HIF-1alpha and P-gp expression was validated by the use of hepatoma tumor spheroids that were either wild type (Hepa1) or mutant (Hepa1C4) for aryl hydrocarbon receptor nuclear translocator (ARNT), i.e., HIF-1beta.
|
12514119 |
2003 |
|
Liver neoplasms
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Reporter gene analyses with a series of nested deletion mutants of the hepatoma type II hexokinase promoter show that a significant fraction of the total activation observed under hypoxic conditions localizes to the distal region where the overlapping HIF-1/E-box sequences are located.
|
11557773 |
2001 |
|
Liver neoplasms
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Hypoxic treatment of various mouse and human hepatoma cell lines led to the expected increase in the amount of PGK1 and PKM2 mRNA, while HIF-1alpha mRNA levels were not significantly elevated.
|
9692838 |
1998 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
BEFREE |
To analyse further the mechanisms underlying induction of the genes identified in the differential display, inducible expression was compared in wild-type mouse hepatoma cells (Hepa-1), and mutant derivatives (c4) which fail to generate HIF-1, due to a functional defect in one component, HIF-1 beta.Two types of response were defined.
|
8917436 |
1996 |