|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1α expression varied with FBXO22, indicating that FBXO22 regulated the expression of HIF-1α and VEGFA and that FBXO22 was a regulator of HIF-1α and VEGF for the control of tumor angiogenesis.
|
30887251 |
2020 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53.
|
30339780 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Vascular endothelial growth factor (VEGF), a crucial factor in tumor angiogenesis, has been reported to be transcriptionally regulated by hypoxia-inducible factor-1 (HIF-1).
|
30906512 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
RLIP76 plays an essential role in tumor angiogenesis through the regulation of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1).
|
30999946 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor angiogenesis, growth, and metastasis and is recognized as an important potential therapeutic target for cancer.
|
30728113 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In hypoxic condition, hypoxia-inducible factor-1α (HIF-1α) is stabilized and translocated into nucleus where it forms heterodimer with HIF-1β and regulates the expression of a plethora of genes involved in different processes, such as cell proliferation, differentiation, apoptosis, vascularization/angiogenesis, tumor invasion and metastasis.
|
30819620 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The hypoxia-inducible factor-1α (HIF-1α) pathway has been implicated in tumor angiogenesis, growth, and metastasis.
|
31006525 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hypoxia-inducible factor 1 (HIF-1) participates in tumor angiogenesis by upregulating target genes, such as vascular endothelial growth factor (VEGF).
|
29416751 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation.
|
30250643 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes tumor angiogenesis via upregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF).
|
30103950 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining.
|
29024813 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In hepatocarcinoma tissues, HIF-1α, and survivin protein expression was positively correlated with VEGF expression, but survivin protein was not related to HIF-1α expression, which indicated that HIF-1α and survivin may inhibit the apoptosis of hepatocarcinoma cells and promote tumor angiogenesis by up-regulating the expression of VEGF protein, thus accelerating the occurrence and development of hepatocarcinoma.
|
29917189 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
It has been postulated that the abnormal hemodynamic profile in CF-LVAD patients may activate the angiogenesis signaling cascade via the HIF (hypoxia-inducible factor)-1α/angiopoietin-2 pathway leading to formation of GIADs.
|
30354557 |
2018 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Artificial overexpression of miR-199a-5p decreased cell proliferation, motility, and tumor angiogenesis and increased apoptosis in PCa cell liness PC-3 and DU145 by directly targeting the 3'-untranslated region (UTR) of HIF-1α mRNA, which reduced HIF-1α levels as well as downstream genes transactivated by HIF-1α (such as VEGF, CXCR4, BNIP3 and BCL-xL).
|
29137361 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The data demonstrated that the SIM antiproliferative effects on melanoma cells were mediated mainly via strong suppressive actions on the B16.F10 cell capacity to support tumor angiogenesis and inflammation, as a result of a high inhibition of the inducible expression of HIF-1α.
|
28521491 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recent studies show that HIF-1 plays a central role in angiogenesis, cancer and cardiovascular disease but also in bacterial infections.
|
27903434 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, LSD1 is a key regulator of HIF1α/VEGF-mediated tumor angiogenesis by antagonizing the crosstalk between PTMs involving HIF1α protein degradation.
|
28534506 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In vitro experiments demonstrated that PHD3 may act as a negative regulator of hypoxia‑inducible factor‑1α and vascular endothelial growth factor, both of which participate in tumor angiogenesis.
|
28901473 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The hypoxia-inducible factor-1α (HIF-1α) plays a critical role in tumor angiogenesis.
|
28710377 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, metformin ameliorated tumor hypoxia and restrained HIF-1α-induced expressions of AAFs through elevating tumor blood perfusion, thus suppressing the excessive tumor angiogenesis.
|
29088755 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We put a special focus on the transcription factor HIF-1α, a master regulator of tumor angiogenesis.The interaction of CDK5 with HIF-1α was tested by Western blot, PCR, reporter gene assay, immunohistochemistry, kinase assay, co-immunoprecipitation, mass spectrometry, and mutation studies.
|
27027353 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
DEK promotes tumor angiogenesis and growth in nude mice in HIF-1α-dependent and -independent manners.
|
26988756 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HIF-1 (hypoxia-inducible factor-1) regulates the expression of more than 70 genes involved in angiogenesis, tumor growth, metastasis, chemoresistance, and radioresistance.
|
27263528 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, F2 suppressed vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 expressions, followed by the inhibition of tumor angiogenesis and cell invasion in a HIF-1α-dependent manner.
|
25385044 |
2015 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Using ovarian and endometrial cancer cell lines, we observed that TM downregulates HIF-1α protein levels and HIF-transcriptional targets involved in tumor angiogenesis and glycolysis, but did not affect HIF-1α protein synthesis.
|
26469226 |
2015 |