|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia.
|
26218850 |
2015 |
|
Schizophrenia
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
β2 microglobulin, HLA-A and Notch4 were all expressed in a pattern where inflammatory illness was associated with increased expression in controls but not in subjects with schizophrenia.
|
23395714 |
2013 |
|
Schizophrenia
|
0.470 |
Biomarker
|
disease |
PSYGENET |
β2 microglobulin, HLA-A and Notch4 were all expressed in a pattern where inflammatory illness was associated with increased expression in controls but not in subjects with schizophrenia.
|
23395714 |
2013 |
|
Schizophrenia
|
0.470 |
Biomarker
|
disease |
PSYGENET |
While searching for the "true" disease gene near the HLA-A gene, we discovered that homozygosity of the HLA-J M80469 pseudogene allele, in combination with HLA-A10 or HLA-A9, was associated with a high risk of schizophrenia (HLA-A10 relative risk = 29.33, p = 0.00019, patients N = 77, controls N = 214).
|
23083632 |
2013 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
While searching for the "true" disease gene near the HLA-A gene, we discovered that homozygosity of the HLA-J M80469 pseudogene allele, in combination with HLA-A10 or HLA-A9, was associated with a high risk of schizophrenia (HLA-A10 relative risk = 29.33, p = 0.00019, patients N = 77, controls N = 214).
|
23083632 |
2013 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
|
22688191 |
2012 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
However, no significant differences of these allelic frequencies were found between the patients and the control subjects, suggesting that the HLA-A gene was unlikely a major risk factor of schizophrenia in this sample.
|
18786593 |
2008 |
|
Schizophrenia
|
0.470 |
Biomarker
|
disease |
PSYGENET |
However, no significant differences of these allelic frequencies were found between the patients and the control subjects, suggesting that the HLA-A gene was unlikely a major risk factor of schizophrenia in this sample.
|
18786593 |
2008 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the results of a family-based candidate-gene study that brings together these two disparate lines of research by assessing maternal-fetal genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia.
|
16960807 |
2006 |
|
Schizophrenia
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated frequencies of HLA-A specificities in schizophrenia patients (ICD-10 and DSM-III-R, n=98) and sex-matched healthy controls (n=392) from population in the southwestern part of Japan.
|
11840504 |
2002 |
|
Schizophrenia
|
0.470 |
Biomarker
|
disease |
PSYGENET |
Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.
|
12165412 |
2002 |
|
Schizophrenia
|
0.470 |
Biomarker
|
disease |
BEFREE |
Thus, no evidence was obtained for an association between HLA-A and schizophrenia from the Japanese population.
|
12165412 |
2002 |
|
Toxic Epidermal Necrolysis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allergic drug reactions are unpredictable; nevertheless, there is increased risk of drug hypersensitivity in (1) patients with cystic fibrosis who receive antibiotics; (2) patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) who receive trimethoprim-sulfamethoxazole or if human leukocyte antigen (HLA)-B*5701+ and receive the antiretroviral agent abacavir; (3) other genetically susceptible populations, e.g., Han-Chinese with HLA-B*1502+ who develop Stevens-Johnson syndrome and toxic epidermal necrolysis from carbamazepine, with HLA-B*5801+ who are at increased risk for such reactions from allopurinol, those with HLA-A*32:01 and receive vancomycin and develop drug reaction with eosinophilia and systemic symptoms syndrome; and (4) patients with a history of compatible allergic reactions to the same medication, similar class, or potentially unrelated medication.
|
31690398 |
2019 |
|
Toxic Epidermal Necrolysis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HLA haplotype analyses indicated that HLA-A*02:06:01 is primarily associated with susceptibility to CM-SJS/TEN with SOCs.
|
31700100 |
2019 |
|
Stevens-Johnson Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allergic drug reactions are unpredictable; nevertheless, there is increased risk of drug hypersensitivity in (1) patients with cystic fibrosis who receive antibiotics; (2) patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) who receive trimethoprim-sulfamethoxazole or if human leukocyte antigen (HLA)-B*5701+ and receive the antiretroviral agent abacavir; (3) other genetically susceptible populations, e.g., Han-Chinese with HLA-B*1502+ who develop Stevens-Johnson syndrome and toxic epidermal necrolysis from carbamazepine, with HLA-B*5801+ who are at increased risk for such reactions from allopurinol, those with HLA-A*32:01 and receive vancomycin and develop drug reaction with eosinophilia and systemic symptoms syndrome; and (4) patients with a history of compatible allergic reactions to the same medication, similar class, or potentially unrelated medication.
|
31690398 |
2019 |
|
Stevens-Johnson Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing.
|
31700100 |
2019 |
|
Toxic Epidermal Necrolysis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reaction with eosinophilia and systemic symptoms, and SJS/TEN in patients treated with carbamazepine.
|
29392710 |
2018 |
|
Toxic Epidermal Necrolysis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We focused on 80 Indian patients with SJS/TEN with severe ocular complications (SOC) and investigated the association of alleles at HLA -A, HLA-B and HLA-C loci; the controls were 50 healthy Indian volunteers.
|
29162886 |
2017 |
|
Toxic Epidermal Necrolysis
|
0.400 |
Biomarker
|
disease |
BEFREE |
SJS and TEN were found to be significantly associated with HLA-A*33:03 and HLA-C*03:02 alleles in both groups of studies with matched controls and population controls.
|
28438823 |
2017 |
|
Toxic Epidermal Necrolysis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In Japanese individuals, HLA-A*02:06, HLA-A*02:07, HLA-A*31:01 and HLA-B*51:01 may be linked to higher risks of TEN.
|
27400826 |
2017 |
|
Toxic Epidermal Necrolysis
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.
|
28570299 |
2017 |
|
Stevens-Johnson Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, HLA-A*24:02 was associated significantly with Stevens-Johnson syndrome induced by the aromatic antiepileptic drugs as a group (<i>p</i> = 1.02 × 10<sup>-5</sup>) and by individual drugs (carbamazepine <i>p</i> = 0.015, lamotrigine <i>p</i> = 0.005, phenytoin <i>p</i> = 0.027).
|
28476759 |
2017 |
|
Stevens-Johnson Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
HLA-A*31: 01 and HLA-B*15:02 association with Stevens-Johnson syndrome and toxic epidermal necrolysis to carbamazepine in a multiethnic Malaysian population.
|
28570299 |
2017 |