|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Neither the BD-associated genetic risk locus within the HLA-B/MICA region nor being on immunosuppressive medications explained the differences between patients and controls.
|
27283393 |
2016 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients.
|
25889189 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51.
|
12209364 |
2002 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest the possibility of a primary association of Behcet disease with MICA rather than HLA-B.
|
9037047 |
1997 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The significant increase of HLA-A*2602 and B*3901 in the patient group without HLA-B*51 suggests that these two alleles might also have some secondary influence on the onset of BD.
|
16671946 |
2006 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus, HLA-B*51 and HLA-Cw*16 seem to confer susceptibility to BD in this patients.
|
18627572 |
2008 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The strong LD patterns between HLA-B and DR antigens in BD suggest that the susceptibility gene to BD could reside between the these two antigens.
|
9575677 |
1998 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that the pathogenic gene of BD is HLA-B51 itself and not other genes located in the vicinity of HLA-B.
|
11053265 |
2000 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece.
|
10440244 |
1999 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, HLA-B*5101 gene from 37 individuals including Japanese, Turkish, Jordanian and Iranian patients and healthy controls were fully sequenced to further clarify the B*5101 gene in association with BD.
|
18700875 |
2008 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) and areas including the major histocompatibility complex class I, genome-wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 receptor (IL-23R), C-C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin-like receptor family members (KLRC4-KLRK1).
|
30341905 |
2019 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since the identification of HLA-B*5101 (and more recently of MICA) as a susceptibility locus for BD, the identification of additional genetic locus/loci, whether inside, or perhaps more importantly outside the MHC has clearly stalled.
|
19684014 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.
|
20875797 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behçet's disease.
|
7591872 |
1995 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%.
|
12723980 |
2003 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The alterations in the nature and affinity of HLA-B*51·peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with BD.
|
28446606 |
2017 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Both HLA-B*51 and MICA*009 are strongly associated with BD in a pure Caucasian BD patient group, and the two alleles are in linkage disequilibrium.
|
16101830 |
2005 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that gene-gene interactions between HLA-B*51 and ERAP1 variants is important for BD development, however, ERAP1 variants which interact with HLA-B*51 may differ among disease phenotypes or populations.
|
30514861 |
2018 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The prevalent distribution in a specific geographical area spanning the Mediterranean basin and Asia, the close association with human leukocyte antigen B*51 in different ethnic groups, and the familial clustering of BD are hallmarks accounting for the strong contribution of a genetic background.
|
16273774 |
2006 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Behçet's disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes.
|
30808881 |
2019 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1.
|
26360328 |
2016 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
The rare TNF-2 polymorphism at the TNF -308 promoter position was associated with HLA-B*50 (not B*51), and was not associated with BD.
|
10519363 |
1999 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although it has been reported that the MHC class I molecule, HLA-B51, is a risk factor for Behçet's disease (BD), contribution of the tumor necrosis factor (TNF) genes, which are located in the vicinity of the HLA-B locus, to the genetic susceptibility for BD has yet to be elucidated.
|
15875188 |
2006 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behçet's disease in a Korean population.
|
22258392 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leukocyte antigen (HLA)-B51 and Behçet's disease to a model of five amino acids of the HLA-B molecule involved in the binding of the antigen, the interactions with receptors on CD8 T cells and natural killer cells, and the signal peptide of HLA-B, suggesting a crucial role of the cellular cytotoxicity on this disease.
|
25405820 |
2015 |