|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in those with psoriasis (p < 0.05).
|
18381784 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for significant HLA-B and HLA-C alleles in multivariate analyses, MICA*016 remained significantly associated with psoriasis [odds ratio (OR) = 5.5, P = 0.008].
|
21457151 |
2011 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our patients with type II psoriasis represented a significant association with the HLA-B*13.
|
16532100 |
2006 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This includes several HLA class I alleles associated with HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97 that mediate HIV-1 peptide binding; and the deletion polymorphism rs67384697 associated with high surface expression of HLA-C. We also found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which respectively encode a natural killer cell activating receptor and its putative ligand, significantly increased psoriasis susceptibility.
|
22577363 |
2012 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Obesity is linked with late-onset psoriasis and PsA, while normal weight is associated with the presence of the HLA-B*27 allele and an earlier onset of the disease.
|
28202737 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It is conceivable that an unknown susceptibility gene, on certain HLA-B-Cw haplotypes, is responsible for the development of psoriasis.
|
15140030 |
2004 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders.
|
22125590 |
2011 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
|
18364390 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
|
17587057 |
2007 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of psoriasis in an Egyptian population.
|
30921485 |
2019 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The human leukocyte antigen-C0602 allele confers the highest risk for psoriasis whereas several human leukocyte antigen-B alleles were identified as 'PsA-specific' genes.
|
25415529 |
2015 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA-B*13 allele and HLA-B*13 Cw*06, TNFa11 b4 c1 d3 e3 haplotypes showed increased frequencies (p < 0.05) in patients with type II psoriasis, which suggests susceptibility to the onset of psoriasis.
|
17101473 |
2007 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
|
18364390 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|
18369459 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Taken together with our recent results demonstrating linkage to HLA-B and -C, this genome-wide scan identifies a psoriasis susceptibility locus at HLA, confirms linkage to 17q, and recommends two novel genomic regions for further scrutiny.
|
9259283 |
1997 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|
18369459 |
2008 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of HLA-B and C alleles in development of psoriasis in patients from North India.
|
9694354 |
1998 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We also conclude that the HLA-B17 allele, which is strongly associated with psoriasis, is unlikely itself to contribute directly to psoriasis susceptibility; rather, the HLA-B locus is probably tightly linked to the PSORS1 locus.
|
9694251 |
1998 |