|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional evidence for increased risk of MS conferred by the European haplotype were found for HLA-B*07:02 and HLA-A*03:01 in African Americans.
|
30653506 |
2019 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Stepwise conditional analysis identified HLA-DRB1*04:05, HLA-B*39:01, and HLA-B*15:01 as being associated with independent MS susceptibility (P<sub>Conditional</sub> < 8.3 × 10<sup>-4</sup>).
|
31382992 |
2019 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Host HLA-B*07 allele influence EBV VL in MS. As HLA-class I molecules present antigens to T lymphocytes and initiate immune response against viruses, these results could support a role for EBV in MS.
|
29587799 |
2018 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA-B*44 (OR 0.58 [95% CI 0.31-1.09]) and HLA-DRB1*04 (OR 0.75 [95% CI 0.42-1.34]) alleles tended to be less frequent in MS patients.
|
27797002 |
2017 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since A*02-Cw*05 is carried by two HLA extended haplotypes characterised by the B*4402 and B*1801 alleles, respectively, the association analysis was extended to HLA B*44 and B*18 in an Italian sample (1445 MS cases and 973 controls) and these associations were verified in a UK cohort (721 MS cases, 408 controls and 480 family trios).
|
21441263 |
2011 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-B*52 was negatively associated with MS only in Muslims (P(Bonferroni)=0.01, OR=0.03).
|
20463743 |
2010 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The MHC class I alleles HLA A*02 and HLA B*44 independently reduce susceptibility to MS, but only HLA B*44 appears to influence disease course, preserving brain volume and reducing the burden of T2 hyperintense lesions in subjects with MS.
|
20713950 |
2010 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
|
20598377 |
2010 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Neither HLA-B nor MICA alleles were found to be associated with MS susceptibility, and only the frequency of HLA-DRB1*01 allele was found to be increased in controls (31% vs 14%, P(c) = 0.011).
|
18588574 |
2008 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using transmission disequilibrium test and haplotype analyses, we found positive associations between MS and several HLA-DRB1*15-HLA-A haplotypes including HLA-DRB1*15-HLA-A*02 (P = 2.41 x 10(-5)) and -HLA-A*03 (P = 8.42 x 10(-6)) and several HLA-DRB1*15-HLA-B haplotypes including HLA-DRB1*15-HLA-B*07 (P = 2.23 x 10(-10)).
|
17584771 |
2007 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Neither HLA-B nor HLA-DR alleles were found to be associated with MS susceptibility.
|
16671949 |
2006 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
LHGDN |
Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis.
|
16459714 |
2006 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA-B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA-B*4422 and HLA-B*4704).
|
12135438 |
2002 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The frequency of HLA-B*5101 was increased in both types of MS patients compared with controls.
|
9894852 |
1998 |
|
Multiple Sclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-A and HLA-B antigens were determined in 24 Coloured patients with multiple sclerosis (MS) and HLA-DR antigens in 16 of these patients.
|
6597862 |
1985 |
|
Multiple Sclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the MS patient group, a much weaker association was noted between BfS and HLA-B7 suggesting either that the Bf locus is musch closer to the HLA-D than the HLA-B locus or (and) that HLA-D and Bf products selectively interact (perhaps on the surface of B lymphocytes) with evolutionary advantage or disadvantage resulting from certain allelic combinations.
|
91230 |
1979 |