|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>HLA-B*58:01</i> Genotyping to Prevent Cases of DRESS and SJS/TEN in East Asians Treated with Allopurinol-A Canadian Missed Opportunity [Formula: see text].
|
31378082 |
2020 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allergic drug reactions are unpredictable; nevertheless, there is increased risk of drug hypersensitivity in (1) patients with cystic fibrosis who receive antibiotics; (2) patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) who receive trimethoprim-sulfamethoxazole or if human leukocyte antigen (HLA)-B*5701+ and receive the antiretroviral agent abacavir; (3) other genetically susceptible populations, e.g., Han-Chinese with HLA-B*1502+ who develop Stevens-Johnson syndrome and toxic epidermal necrolysis from carbamazepine, with HLA-B*5801+ who are at increased risk for such reactions from allopurinol, those with HLA-A*32:01 and receive vancomycin and develop drug reaction with eosinophilia and systemic symptoms syndrome; and (4) patients with a history of compatible allergic reactions to the same medication, similar class, or potentially unrelated medication.
|
31690398 |
2019 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Aboriginal Australians, phenytoin DRESS appears distinctly linked to HLA-B*56:02 with an allele carriage rate substantially higher than in Europeans, but also with considerable regional variation.
|
31206740 |
2019 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Occupational trichloroethylene hypersensitivity syndrome (OTHS) clinically manifests as generalized severe rash resembling drug-induced hypersensitivity syndrome (DIHS) and afflicts predominantly HLA-B*13:01 gene carriers after their exposure to trichloroethylene.
|
30758654 |
2019 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study indicates that HLA-B*13:01 is strongly associated with dapsone DRESS and describes a functional role for the HLA-restricted immune mechanism induced by dapsone.
|
29458119 |
2018 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*1301 was related to salazosulphapyridine-induced DRESS.The mortality rate was 6% (3/52).
|
29242946 |
2018 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel genetic biomarker, HLA-B*15:13, showed significant association with PHT-SJS/TEN (53.8%, 7/13 cases) (odds ratio (OR) 11.28, P=0.003) and PHT-DRESS (100%, 3/3 cases) (OR 59.00, P=0.003) when compared with PHT-tolerant controls (9.4%, 3/32 controls).
|
26927288 |
2017 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data implicate the prevalent African allele HLA-B*53:01 in the immunopathogenesis of raltegravir-induced DRESS syndrome.
|
28369189 |
2017 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Non-genetic factor, omeprazole co-medication, was strongly associated with PHT-induced DRESS/DHS in addition to variants in HLA-B and CYP2C genes.
|
28391407 |
2017 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrated an association between HLA-B*13:01 and dapsone-induced SCARs including Stevens-Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms in nonleprosy patients.
|
28885988 |
2017 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
By comparison, CBZ-induced MPE/DRESS had no association with HLA-B*15:02, but linked to HLA-A*31:01 (Pc=2.7×10(-3); OR (95% CI)=6.86(2.4-19.9), and HLA-B*51:01 (Pc=0.01; OR (95% CI)=4.56(2.0-10.5)).
|
24268988 |
2014 |
|
Drug Hypersensitivity Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*13:01 might serve as a potential genetic marker for reducing the prevalence of SASP-induced DRESS.
|
25303297 |
2014 |