|
Hepatitis B, Chronic
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Hepatitis B, Chronic
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Some variants of the HLA-DP locus (HLA-DPA1 A allele and HLA-DPB1) protect against progression of chronic hepatitis B infection.
|
24654629 |
2014 |
|
Hepatitis B, Chronic
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Hepatitis B, Chronic
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
Hepatitis B, Chronic
|
0.440 |
AlteredExpression
|
disease |
BEFREE |
Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver.
|
21346778 |
2011 |
|
Hepatitis B, Chronic
|
0.440 |
Biomarker
|
disease |
CTD_human |
Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1.
|
19349983 |
2009 |
|
Hepatitis B, Chronic
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1.
|
19349983 |
2009 |
|
Granulomatosis with polyangiitis
|
0.400 |
SusceptibilityMutation
|
disease |
ORPHANET |
Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.
|
28029757 |
2017 |
|
Granulomatosis with polyangiitis
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
|
23740775 |
2013 |
|
Dermatitis, Irritant
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association of MHC region SNPs with irritant susceptibility in healthcare workers.
|
27258892 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection.
|
31290749 |
2019 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DPA1*01:03:01 was correlated with lower ORs of undetectable anti-HBs titers, while -DPA1*02:02:02 and -DPB1*05:01:01 were correlated with higher ORs.
|
31515149 |
2019 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated, for the first time, that expression of HLA-DPA1 alleles and rs3077 affected the risk of HBV infection.
|
30267609 |
2019 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DPA1 rs3077 variant was associated with a protective effect increasing the spontaneously resolved HBV infection (OR 0.64, 95% CI 0.41-0.98, P=0.039, dominant genetic model).
|
27051043 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects.
|
24520320 |
2014 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We compared the SNPs in the HLA-DPA1 gene (rs3077) and the IFN-γ receptor-2 gene (rs2284553 and rs9808753) of 100 treatment-naive hepatitis B e antigen (HBeAg)-negative CHB patients with undetectable HBV DNA with 100 age- and sex-matched controls with HBV DNA > 2000 IU/mL.
|
23980639 |
2014 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive).
|
23825586 |
2013 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection.
|
23326374 |
2013 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Examination of large numbers of cohorts revealed that several SNPs in both HLA-DPA1 and HLA-DPB1 loci are associated with persistent HBV infection in Asian populations.
|
24023482 |
2013 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians.
|
22448225 |
2012 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.
|
22737229 |
2012 |