|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
Response to hepatitis B vaccination is co-determined by HLA-DPA1 and -DPB1.
|
31515149 |
2019 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, DPB1*04:02 possessing rs1042169 G - rs9277355 C - rs9277356 A is an independent predictor of the HB vaccine response in Koreans.
|
31243853 |
2019 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
When frequencies of DRB1-DQB1 haplotypes and DPB1 alleles were compared between low immune responders and HBV patients, significant associations were identified for three DRB1-DQB1 haplotypes, and no association was identified for any of the DPB1 alleles.
|
29534301 |
2018 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Researches reported single nucleotide polymorphism (SNP) of HLA-DP associated with HBV infection and autoimmune diseases such as SLE.
|
29476350 |
2018 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the 3' untranslated region of HLA-DPB1, rs9277534, is associated with HLA-DPB1 expression. rs9277534 has been linked to hepatitis B virus recovery/persistence and the risk of graft-versus-host disease with HLA-DPB1 mismatching transplantation of hematopoietic cells, but its role along with that of HLA-DP expression in AIH have not been fully clarified.
|
30093645 |
2018 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to evaluate the relation of OBI to HLA-DP single nucleotide polymorphisms (SNPs) encoding antigen-binding sites for the immune response to HBV infection.
|
29061159 |
2017 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.
|
28267888 |
2017 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
Previous studies demonstrated that variations in the human leukocyte antigen (HLA) class II (HLA-DPB1 and HLA-DQB2 genes) are related to the chronic HBV infection.
|
28613373 |
2017 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results, for the first time, demonstrate that HLA-DPB1 gene rs9277535A allele has a major effect on the risk of persistent HBV infection.
|
28119119 |
2017 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
After transplant, 10 recipients who were positive for HBsAg or with elevation in HBV virus load were regarded as HBV recurrence.No significant association of HLA-DP/DQ polymorphisms with HBV recurrence or transplant etiology was observed (P < .05).
|
28640108 |
2017 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DP variants with the responsiveness to Hepatitis B virus vaccination in Korean Infants.
|
27083422 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Host factors including gender, age, family history, HLA-DP, and viral factors including HBV DNA, genotypes, precore mutations, pre-S deletions, and hepatitis B surface antigen (HBsAg) level are associated with the development of these complications.
|
26840752 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression.
|
27051043 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that HLA-DP/DQ polymorphisms can affect susceptibility and resistance to HBV infection in Chinese populations, and are possibly linked to race and sex.
|
27291710 |
2016 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All the minor alleles of these HLA-DP candidate SNPs were correlated with lower likelihoods of nonresponse to HB vaccine.
|
25389088 |
2015 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
In sum, we showed, for the first time, that the HLA-DP/DQ clusters contribute independently to HBV infection, and the 3'-UTR region of HLA-DPB1 represents an important functional region involved in HBV infection.
|
26197724 |
2015 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
Many GWASs conclude that the genetic variants in the HLA region (HLA-DP, HLA-DQ, HLA-DR and MICA), KIF1B, DEPDC5 and PNPLA3 influence HBV infection, its clinical course and the response to hepatitis B vaccination.
|
25475418 |
2015 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
Identification of the HLA-DPB1 genotypes associated with susceptibility to and protection from CHB infection is essential for future analysis of the mechanisms responsible for immune recognition of hepatitis B virus antigens by HLA-DPB1 molecules.
|
26449183 |
2015 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2).
|
25103089 |
2015 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To derive a more precise estimation of the relationship between HLA-DP polymorphisms and various outcomes of HBV infection, a meta-analysis of 62,050 subjects from 29 case-control studies was performed.
|
26462556 |
2015 |
|
Hepatitis B
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
Hepatitis B
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma.
|
24520320 |
2014 |