|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
26272072 |
2016 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The trans-heterodimer between two RA non-associated HLA genes can render susceptibility to develop arthritis in humanized mice, DQA1*0103/DQB1*0604, suggesting a role for DQ α chains in pathogenesis.
|
26524976 |
2016 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we found that the SNP of rs9272219 in HLA-DQA1 is a potential susceptibility locus in RA of Han Chinese population; the results suggest that HLA-DQA1 may be related to the development of RA.
|
25550865 |
2014 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population.
|
23951149 |
2013 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.
|
21653640 |
2011 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that the associations between HLA-DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.
|
20141563 |
2010 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine the distribution of HLA-DRB1 and DQB1/DQA1 alleles in a cohort of patients with RA in remission and to determine the association between these HLA alleles and the persistence of remission.
|
11874840 |
2002 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A synergistic effect for the susceptibility to RA can be found between HLA-DR4 and HLA-DQA1*0302 or DQA1*0303.
|
11482129 |
2001 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
DQ3 (DQBI*03 and *04 combined with DQA1*03) and DQ5 (DQB1*0501/DQA1*0101) alleles predisposed individuals to RA independently of SE-positive DRB1 alleles.
|
11229460 |
2001 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our results show that HLA-DQB1*03/DQA1*03 (or DRB1*04) predisposes to RA more than HLA-DQB1*0501/DQA1*01 (i.e., DRB1*01 and DRB1*10).
|
11334677 |
2001 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nonetheless, there is a strong case for the role of DQB1*03 and *04 combined with DQA1*03 in susceptibility to severe RA while DQB1*0501 combined with DQA1*0101 and *0104 weakly predisposes to a mild form of RA.
|
11163080 |
2000 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To examine the genetic contribution of HLA and non-HLA genes in the etiopathogenesis of rheumatoid arthritis (RA), 60 Caucasian multiplex families were identified and DNA analyzed for over 52 markers including DRB1, DQA1 and DQB1 alleles.
|
11197302 |
1999 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that HLA-DRB1*0405 (RR = 6.6, P<10(-6)), DQA1*03 (RR = 5.2, P<10(-6)), DQB1*04 (RR = 3.5, P<0.002) alleles were useful markers of susceptibility to RA in Koreans.
|
10674968 |
1999 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1 alleles carrying the motif DERAA in their third hypervariable region, i.e., *0103, *0402, *1102, *1103, *1301, and *1302, provide a long-lasting protection against RA in DQA1*0101/04- but not in DQA1*0301-positive individuals.
|
9799335 |
1998 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since the associations between DRB1 genes and susceptibility to RA are incomplete, in this study we examined the CA repeat polymorphic marker DQCAR, located between DQA1 and DQB1 genes, alleles in 98 adult patients with seropositive RA and 100 normal healthy controls.
|
9694353 |
1998 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The occurrence of vasculitis in RA is not associated with the shared epitope.DQA1, or DQB1 alleles.
|
9150071 |
1997 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The frequency of the HLA-DR4-DQ4 haplotype (DRB1(*)0405-DQA1(*)0302-DQB1(*)0401) is significantly increased in Japanese patients with rheumatoid arthritis (RA) and DRB1(*)0405-binding peptide motifs were identified in our previous studies.
|
8671664 |
1996 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To examine the role of HLA-DQ molecules in arthritis, we generated transgenic mice expressing the DQA1*0301 and DQB1*0302 genes from an RA predisposing haplotype (DQ8/DR4Dw4).
|
8551230 |
1996 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Polymorphism of HLA-DRB, -DQA1, and -DQB1 in rheumatoid arthritis in Asian Indians: association with DRB1*0405 and DRB1*1001.
|
9157087 |
1996 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
It is concluded that HLA-DQA region genes may be an important susceptibility factor for the development of gold induced nephropathy in patients with RA.
|
8484697 |
1993 |
|
Rheumatoid Arthritis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the distribution of DRB1, DQA1, DQB1, and DPB1 allelic variants in 48 rheumatoid arthritis (RA) patients, compared with 109 Italian random controls, using PCR amplification and hybridization with specific oligonucleotides.
|
1429034 |
1992 |
|
Rheumatoid Arthritis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The frequencies of DNA fragments associated with the following HLA class II genes were increased in RA when compared to normal controls: DRB1*04 (DR4) (relative risk, RR = 7.4, P less than 10(-3), DRB4*0101 (DRw53) (RR = 9.6, P less than 10(-3), DQA1*0301 (RR = 9.6, P less than 10(-3), DQB1*0301 (DQw7) (RR = 2.8, P less than 0.05, 'corrected' P greater than 0.05), and DQB1*0302 (DQw8) (RR = 4.5, P less than 10(-2).
|
1686751 |
1992 |