|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Within HLA, some variants of the DRB1, DQA1 and DQB1 genes appear to be possible predictors of the development and recurrence of Graves' disease.
|
30484670 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Some gene polymorphisms, such as <i>CTLA4</i> rs231775, human leukocyte antigen polymorphisms (<i>DRB1*03, DQA1*05</i>, and <i>DQB1*02</i>) might be associated with the high recurrence risk in GD patients.
|
29085334 |
2017 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
CagA-positive H. pylori, negative HLA-DQA1 0201, or positive HLA-DQA1 0501 may increase the risk of GD.
|
23954255 |
2013 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1(*)03-DQB1(*)02-DQA1(*)05) and a protective effect for DR7 (DRB1(*)07-DQB1(*)02-DQA1(*)02).
|
18449200 |
2008 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1(*)03-DQB1(*)02-DQA1(*)05) and a protective effect for DR7 (DRB1(*)07-DQB1(*)02-DQA1(*)02).
|
18449200 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude, that HLA DQA1*0501 and DQA1*0501-DQB1*0201 (DQ2) are strongly associated with Graves' disease in both populations.
|
17714036 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the major histocompatibility complex (MHC) class II-encoded HLA-DRB1-DQA1-DQB1 haplotype with Graves' disease (GD) has been known for several years.
|
17597093 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, DRB1*1602 allele and closely linked haplotype, DRB1*1602-DQA1*0102-DQB1*0502, might serve as a marker for genetic susceptibility to GD in Asian population.
|
16451208 |
2006 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians.
|
15993720 |
2005 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown.
|
15558498 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with Graves' disease alone, the haplotype frequency of DRB1*0803-DQA1*0103-DQB1*0601 were significantly higher than those in controls, suggesting that the susceptibility haplotypes for group B APS III differed from those for Graves' disease alone.
|
16254435 |
2005 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, a subgroup of all investigated microchimerism-positive mother-child pairs and women with Hashimoto's thyroiditis and Graves' disease more often had the susceptibility alleles HLA DQA1*0501-DQB1*0201 or DQB1*0301.
|
15531546 |
2004 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined the HLA-DR and HLA-DQA1 association in 112 unrelated patients with APS II (n = 29), APS III (n = 83) and 184 unrelated patients with single-component diseases without further manifestations of APS: Graves' disease (n = 70), Hashimoto's thyroiditis (n = 53), autoimmune Addison's disease (n = 15), vitiligo (n = 16) and alopecia (n = 30), and 72 healthy controls - German Caucasians - to identify possible predisposing and protective HLA class II alleles in APS.
|
12734793 |
2003 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the Brazilian population comprises individuals of several ethnic backgrounds, these results corroborate the participation of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles as susceptibility markers for GD, and emphasize the participation of the HLA-DQB1*0602 allele as conferring protection against the development of the disease.
|
11272094 |
2001 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Graves' disease (GD) is associated with the histocompatibility leucocyte antigen (HLA) haplotype A*01-B*0801-DRB1*0301-DQA1*0501-DQB1*0201 (or B8/DR3) whereas autoimmune hypothyroidism (AIH) has been weakly associated with HLA DRB1*03, *04 and *11/*12 alleles (or DR3, DR4 and DR5).
|
11678832 |
2001 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the presence of the HLA DQA1*0501 and DRB1*0301 antigens in Greek patients with Graves' disease.
|
11263477 |
2001 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As expected, we found that DRB1*03 and DQA1*0501 (OR = 3.6, P = 0.029 and OR 2.35, P = 0.0373, respectively) were associated with GD.
|
11477614 |
2001 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*0301 allele was the primary susceptibility allele for GD, however, because the susceptibility provided by DQA1*0501 was most likely due to it being in linkage disequilibrium with DRB1*0301.
|
11146462 |
2000 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that DRB3*0202, particularly when found with DQA1*0501 in a haplotype is a susceptible gene(s) for Graves' disease in adult African Americans.
|
10770195 |
2000 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results show that association of the LMP 2 locus with Graves' disease is due to linkage disequilibrium with the associated HLA haplotype DRB1*0304-DQB1*02-DQA1*0501.
|
10468973 |
1999 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were to examine the HLA-DQA1 and DQB1 associations with Graves' disease in Chinese children.
|
10468909 |
1999 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Graves' disease (GD) is an autoimmune thyroid disorder which is associated with the human leucocyte antigens HLA-DR3 and DQA1* O501 in Caucasians.
|
9561915 |
1998 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results show that linkage disequilibrium between GD and the HLA class II region is due to the extended haplotype DRB1*0304-DQB1*02-DQA1*0501.
|
9768636 |
1998 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that HLA-DRB1*0301 and DQA1*0501 are associated with susceptibility to Graves' disease.
|
9458117 |
1997 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Graves' disease is an autoimmune disorder in which HLA DQA1*0501 and DQB1*0201 confer predisposition.
|
9027960 |
1997 |