|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among other MG subgroups and with less significance, DRB1*0101 DQA1*0101 DQB1*05 haplotype (P=0.016, OR=3.68) had positive association with pure ocular MG, and DRB1*03 DQA1*0501 DQB1*0201 haplotype (P=0.024) had negative association with thymomatous MG.
|
26671138 |
2015 |
|
Myasthenia Gravis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Its correlation to the HLA haplotype DQA1*03:02/DQB1*03:03:02 might explain the phenotypic difference of MG between Han Chinese and Caucasians.
|
22503410 |
2012 |
|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
Myasthenia Gravis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Patients with thymomatous MG were positively associated with DQA1 *0401(P=0.011, OR:4.57, 95% CI 1.40-14.90) and DQB1 *0604 (P=0.001, OR:4.01, 95% CI 1.65-9.73) as compared to MG patients without thymoma.
|
21917268 |
2012 |
|
Myasthenia Gravis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Among the subgroups, DQB1*02 was significantly more frequent in EOMG (OR: 1.8), in women with MG (OR: 2.4), and in women with EOMG (OR: 2.8), whereas DQA1*0102 and DQB1*502 (OR: 2.3 for both) were increased and DQA1*0103 (OR: 0.04) was decreased in men with MG. Seropositivity was associated with both DQA1*03 (OR: 12.1) and DQB1*0302 (OR: 14.2) in the patient group.
|
16720217 |
2006 |
|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Among the subgroups, DQB1*02 was significantly more frequent in EOMG (OR: 1.8), in women with MG (OR: 2.4), and in women with EOMG (OR: 2.8), whereas DQA1*0102 and DQB1*502 (OR: 2.3 for both) were increased and DQA1*0103 (OR: 0.04) was decreased in men with MG. Seropositivity was associated with both DQA1*03 (OR: 12.1) and DQB1*0302 (OR: 14.2) in the patient group.
|
16720217 |
2006 |
|
Myasthenia Gravis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These date suggest that LG type of MG may present a particular subset of childhood-onset MG, which is associated with the specific HLA subtypes DRB1*1302/DQA1*0102/DQB1*0604 and DRB1*0901/DQA1*0301/DQB1*0303.
|
15003812 |
2004 |
|
Myasthenia Gravis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Oligotyping performed among ethnically mixed Venezuelan patients with myasthenia gravis (MG) and controls has revealed positive associations of HLA class I A*31, B*08, B*39, B*40, C*15, C*17, and class II DRB1*09 and negative associations of DQB1*06 and DQA1*02 with the disease.
|
14700596 |
2004 |
|
Myasthenia Gravis
|
0.200 |
Biomarker
|
disease |
BEFREE |
We used transgenic mice expressing two different DQ molecules, DQ8 (DQA1*0301/B1*0302) and DQ6 (DQA1*0103/B1*0601), to evaluate the role of HLA-DQ genes in MG.
|
9574516 |
1998 |
|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of the AChRalpha-subunit gene (CHRNA), DQA1*0101, and the DR3 haplotype in myasthenia gravis. Evidence for a three-gene disease model in a subgroup of patients.
|
9237805 |
1997 |
|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, two different DQ2 haplotypes (DQA1*0501-DQB1*0201 and DQA1*0201-DQB1*0201) were positively and the DQA1*0103 allele was negatively associated with MG. Susceptibility and resistance to MG in Swedish patients is mediated by HLA-DQ.
|
8882423 |
1995 |
|
Myasthenia Gravis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Chinese Singaporean myasthenia gravis (MG) patients are associated with three HLA haplotypes: Cw1 B46 DRB1*0901 DQB1*0303 DQA1*03, DRB1*14 DRB3*0202 DQB1*0503 DQA1*0101 and DRB1*1202 DRB3*0301 DQB1*0301 DQA1*0601.
|
8508049 |
1993 |