Disease: Dermatomyositis, Childhood Type ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). 28158183 2017
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE At diagnosis of juvenile DM in 61 children prior to the initiation of treatment, tumor necrosis factor alpha (TNFalpha) -308 allele and DQA1*0501 status was determined, juvenile DM Disease Activity Scores (DAS) were obtained, and nailfold capillaroscopy was performed. 18240225 2008
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 Biomarker disease BEFREE In a logistic regression model, DRB1*0301 and DQA1*0201 were the strongest risk and protective factors, respectively, for juvenile DM. 17133612 2006
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 Biomarker disease BEFREE The combination HLA-B52, DRB1*15021, DQA1*0103, and DQB1*0601 may contribute to the pathogenesis of JDM in Japanese patients. 15338511 2004
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 Biomarker disease BEFREE The purpose of this study was to compare the gene expression profiles in muscle biopsies of four untreated DQA1*0501(+) JDM children with profiles from children with a known necrotizing myopathy (Duchenne muscular dystrophy), as well as an in vitro antiviral model (NF90), and healthy pediatric controls. 11937576 2002
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 Biomarker disease BEFREE We speculate that DQA1*0501 is associated with JDM susceptibility to an infectious process, eliciting and activating NK cells early in the disease course. 11564368 2001
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE The 2 patients were shown to share the HLA-DQA1*0501 allele, known to be associated with susceptibility to JDMS. 10606384 1999
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 Biomarker disease BEFREE DQA1*0501 confers genetic risk for JDMS; we cannot exclude the effects of alleles at other linked loci that were not studied or interactive effects between DQA1 alleles and alleles at other loci. 9598907 1998
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE We have previously shown that juvenile dermatomyositis is associated with the HLA-DQA1*0501 allele. 9550430 1997
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE Association of the HLA-DQA1*0501 allele in multiple racial groups with juvenile dermatomyositis. 8666549 1995
CUI: C0263666
Disease: Dermatomyositis, Childhood Type
Dermatomyositis, Childhood Type 		0.100 GeneticVariation disease BEFREE Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1 *0501 on non-DR3 haplotypes in Caucasian JDMS. 1783570 1991