|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previously, a large-scale genome-wide association study described an association between human leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate the association between HLA-DQB1 and PA. Genotypic and allelic profiles were established for 311 Caucasian members of a well-described Canadian group of children with PA and 226 Caucasian controls.
|
23443026 |
2013 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among 66 diabetics, carriers of the HLA-DQB1*0201 allele were at lower risk of having any asthma symptoms than non-carriers (25.5 vs. 53.3%, p = 0.04).
|
19319467 |
2010 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
There was decreased frequency of HLA-DQB1*03 in Alternaria-sensitive moderate-severe asthma, suggesting HLA-DQB1*03 may be protective of the development of Alternaria-sensitive severe asthma.
|
20486920 |
2010 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DR/DQ region on chromosome 6p21.3 was also associated with asthma: rs1063355 in the 3' untranslated region of HLA-DQB1 (P = 9.55E-06).
|
20159242 |
2010 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Conversely, HLA-DQB1*0501 and 0602 were decreased in asthmatics compared to normal controls (7.5% vs. 13.5%, P-value= 0.05; and 4% vs. 12.5%, P-value= 0.002, respectively).
|
19052351 |
2008 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Adjusting for family history of asthma or atopy, gender, low birth weight, season of birth, HLA DRB1*04, and HLA DQB1*0302, the hazards ratio for HLA DRB1*03 carriers was 1.8 (95% confidence interval: 1.1-2.9, P= 0.020).
|
17212706 |
2007 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The allele frequencies of HLA-DRB1(*)1302 (18.1%) and HLA-DQB1(*)0609 (10.1%) in aspirin-induced urticaria were significantly higher than in aspirin-intolerant asthma (5.3%, P=0.0004; 2.0%, P=0.0024) and in normal controls (8.1%, P=0.0005; 3.2%, P=0.0008), and they remained significant after correcting for multiple comparisons.
|
15784113 |
2005 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DQA1 * 0104 allele and HLA-DQB1 * 0201 allele were implicated in susceptibility to asthma and atopy, HLA-DQA1 * 0301 allele and HLA-DQB1 * 0301 might be protective factor against asthma.
|
12890388 |
2003 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The alleles HLA-DQA1 * 0104 and HLA-DQB1 * 0201 are correlated with the susceptibility to asthma among Northern of Han nationality.
|
11953202 |
2002 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma.
|
10792356 |
2000 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Evaluation of major histocompatibility complex (MHC) class II genes in exposed subjects who develop toluene diisocyanate (TDI) asthma has shown a negative association with HLA-DQB1*0501 and a positive association with HLA-DQB1*0503 alleles.
|
9351595 |
1997 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results confirm the hypothesis that HLA-DQB1 * 0503 has a role in conferring susceptibility to TDI-induced asthma and that residue 57 of HLA-DQB1 is a potentially critical location.
|
8777952 |
1996 |