Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT HLA-C*01 is a Risk Factor for Crohn's Disease. 26891255 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The DRB3*0301/DRB1*1302 haplotype is the only significant MHC class II association noted in white people with Crohn's disease and represents the strongest association of any MHC or non-MHC locus with this disease. 10189846 1998
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We conclude that BTNL2 does not contribute to the susceptibility to Japanese CD but is associated with Japanese UC because of the strong LD with HLA-DRB1*1502. 17610417 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE No significant associations were found between any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human leukocyte antigen (HLA) showed a significant increase in heterozygosity at the FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared with HLA-DRB1*0103 noncarriers. 17389014 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS. 21699788 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis. 31518029 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk. 23942620 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease LHGDN A positive association between the HLA-DRB1*0103 allele and CD was detected in non-Jewish, familial cases (p = 0.0002), with risk for CD increased by 6.7 fold by the presence of an HLA-DRB1*0103 allele as compared to 1.9 fold and 19 fold by a single or two CARD15 variant alleles, respectively. 15046222 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE These results show a significant association of the homozygous HLA-DRB1*07 genotype with UC and CD and of several HLA DR/DQ alleles and haplotypes with the clinical phenotypes of these diseases in Tunisian patients. 22224635 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The HLA-DRB1*07 was the only HLA class II allele found to be significantly associated with Crohn's disease (relative risk (RR) = 1.9, 95% CI: 1.66 to 2.14; p = 0.0001). 8707084 1996
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We confirmed that carriage of the HLA-DRB1*0103 allele is strongly associated with isolated colonic CD (14.9% versus 4.0%; P = 0.000016; OR 4.6, 95% CI 2.25-9.47) and report the novel association of this allele with time to first surgical event (log rank P = 0.001). 18521924 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE As a whole, after applying Bonferroni's correction for multiple comparisons, no significant association of HLA-DRB1 alleles with Crohn's disease or ulcerative colitis was found. 15690658 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The strong negative association between the DRB1*03 allele and Crohn's disease suggests that the HLA-DRB1*03 allele mediates 'resistance' to Crohn's disease. 8881812 1996
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. 23266558 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A positive association between the HLA-DRB1*0103 allele and CD was detected in non-Jewish, familial cases (p = 0.0002), with risk for CD increased by 6.7 fold by the presence of an HLA-DRB1*0103 allele as compared to 1.9 fold and 19 fold by a single or two CARD15 variant alleles, respectively. 15046222 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE These results indicated that both of HLA-DRB1 and TNFA promoter polymorphisms contribute to the susceptibility to CD in an independent manner. 11196680 2000
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We were able to replicate the association of the IL23R variants with CD as well as HLA-DRB1*0103 with UC; confirmation of TNFRSF1A association with UC needs additional studies. 18338763 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The carrier frequency of the DRB1*0103 allele was found to be 10-fold higher in Crohn's disease patients with pure colonic involvement than in healthy controls (38.5% vs. 3.2%; p = 0.0002). 12656131 2003
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). 26605347 2015
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Manager 5.2 and Stata 11.0. 25546242 2015
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE Classic HLA allele imputation analysis identified HLA-DRB1*1501 and HLA-DQB1*0602, each highly correlated with one another, as most strongly associated with SLE. 26663301 2016
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE No correlation was found between TNF promoter and HLA-DRB1 genotypes and any SLE classification criterion or disease manifestation. 10643708 2000
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE The 7 SNPs and 4 HLA-DRB1 alleles associated with SLE did not display strong associations with ANA positivity. 25186300 2014
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE Although no HLA-DRB1 allele was found to be significantly associated with SLE, the associations with DQB1*0501 and TNF2 suggest that DQB1 and tumor necrosis factor a may be important genetic factors in SLE susceptibility in the Chinese population in Taiwan. 9182925 1997
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.700 GeneticVariation disease BEFREE This may suggest that HLA class II molecules themselves and/or an unknown susceptibility gene located near the DQA1 and DRB1 loci are involved in the pathogenesis of SLE. 7481564 1995