|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 gene is the major genetic determinant in HLA class II region for children with type 1 AIH.
|
15158329 |
2004 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM.
|
21067577 |
2010 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles of 76 children with pAILD (autoimmune hepatitis [AIH], autoimmune sclerosing cholangitis [AISC], primary sclerosing cholangitis [PSC]) and of 50 healthy blood donors as control group were analyzed retrospectively.
|
26567543 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.
|
9178696 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to the univariate analysis, overlapping features of autoimmune hepatitis (rPSC in 5/5, <i>P</i> ≤ 0.05) and <i>HLA-DRB1*07</i> in the donor (rPSC in 10/15, <i>P</i> ≤ 0.05) represent other potential risk factors for rPSC, while the <i>HLA-DRB1*04</i> (rPSC in 0/6, <i>P</i> ≤ 0.05), <i>HLA-DQB1*03</i> (rPSC in 1/11, <i>P</i> ≤ 0.05), and <i>HLA-DQB1*07</i> (rPSC in 0/7, <i>P</i> ≤ 0.05) recipient alleles may have protective roles.
|
30487703 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also the role of HLA-DRB1 genotype has not been evaluated, though it's associated with fibrosis in autoimmune hepatitis.
|
27333038 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined.
|
17020818 |
2007 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
American patients with type 1 autoimmune hepatitis had DRB1*03 alleles more commonly than the German patients with type 2 disease (51% vs 17%, p = 0.03) and DRB1*0301 occurred more frequently in the type 1 patients (51% vs 17%, p = 0.03).
|
9399751 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients.
|
17722299 |
2006 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1.
|
26693492 |
2015 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively).
|
18022727 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis.
|
15763345 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic susceptibility to autoimmune hepatitis is strongly associated with HLA-DRB1 alleles.
|
20933106 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA alleles appear to influence the exact phenotype-the most interesting apparent association being between HLA-DRB1*0301-DQB1*0201, liver-kidney microsome autoantibodies (anti-CYP1A2), and autoimmune hepatitis.
|
22344197 |
2012 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1*03-DRB1*04 is a risk factor for type-1 autoimmune hepatitis, and its impact on outcome relates to the diversity of DRB1*04 alleles that encode a critical motif.
|
17105585 |
2006 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
LHGDN |
HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients.
|
17510796 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis.
|
20957499 |
2011 |