|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis.
|
20957499 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls.
|
1354193 |
1992 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis.
|
21480110 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1*03-DRB1*04 is a risk factor for type-1 autoimmune hepatitis, and its impact on outcome relates to the diversity of DRB1*04 alleles that encode a critical motif.
|
17105585 |
2006 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 gene is the major genetic determinant in HLA class II region for children with type 1 AIH.
|
15158329 |
2004 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide evidence that specific residues in the DR beta polypeptides predispose to autoimmune hepatitis in white patients and genes linked to DRB3*0101 and DRB1*0401 may determine two clinically distinct disease patterns.
|
8119685 |
1994 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
American patients with type 1 autoimmune hepatitis had DRB1*03 alleles more commonly than the German patients with type 2 disease (51% vs 17%, p = 0.03) and DRB1*0301 occurred more frequently in the type 1 patients (51% vs 17%, p = 0.03).
|
9399751 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes.
|
22797478 |
2010 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.
|
9178696 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the HLA-DRB1*0405 allele is associated with type 1 AIH in Japanese, the exact genetic etiology of AIH remains undefined.
|
17020818 |
2007 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis revealed that the HLA-DRB1*04:05 allele (P < 0.001, OR = 4.61) and rs9277534 (P = 0.004, OR = 1.67) were independently associated with AIH susceptibility. rs9277534G in the HLA-DP gene is an eQTL that affects gene expression and may contribute to AIH susceptibility.
|
30093645 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1*1301 and DRB1*0301 alleles.
|
17927716 |
2007 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively).
|
18022727 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles of 76 children with pAILD (autoimmune hepatitis [AIH], autoimmune sclerosing cholangitis [AISC], primary sclerosing cholangitis [PSC]) and of 50 healthy blood donors as control group were analyzed retrospectively.
|
26567543 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study therefore reveals that different HLA-DRB1 allotypes confer susceptibility to AH in children and adults and raises the possibility that PAH and AAH may be triggered by different factors.
|
10573514 |
1999 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of HLA alleles B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 and possibly A*01:01 enhances the risk of AIH (type 1) in Spanish patients.
|
27206238 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The predisposing association of DRB1*04:01 (P = 0.0006, corrected P [Pc] = 0.0193, odds ratio [OR] 2.97, 95% confidence interval [CI] 1.62-5.43), DRB1*04:05 (P = 1.89×10-21, Pc = 5.86×10-20, OR 3.41, 95% CI 2.65-4.38), and DQB1*04:01 (P = 4.66×10-18, Pc = 6.99×10-17, OR 3.89, 95% CI 2.84-5.33) and the protective association of DRB1*13:02 (P = 0.0003, Pc = 0.0080, OR 0.48, 95% CI 0.32-0.72) with Japanese type 1 AIH were observed.
|
29088299 |
2017 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In 32 patients and 48 healthy controls, polymerase chain reaction amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune hepatitis.
|
12519226 |
2003 |