|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allele frequencies of 40 established and suggested GD/AITD genetic risk variants (39 SNPs and HLA-DRB1*03) were compared between POGD (N = 179), AOGD (N = 1088) and healthy controls.
|
30358895 |
2019 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T1D protective allele DRB1*12:02 was shown to be protective against Graves' disease in our previous report.
|
29383806 |
2018 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the combinations such as 'DRB1*10+AA' (PL: p=1.8×10<sup>-6</sup>; HT: p=0.003) and 'DRB1*15+AA' (PL: p=0.006; GD: p=0.011) were decreased in patients showing a protective association.
|
29174716 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Within HLA, some variants of the DRB1, DQA1 and DQB1 genes appear to be possible predictors of the development and recurrence of Graves' disease.
|
30484670 |
2018 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the associations of genetic variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced agranulocytosis and in 140 patients with Graves' disease (GD) as controls.
|
28931918 |
2017 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
|
26029868 |
2015 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The development of CD in patients with GD was strongly associated with HLA-DQ2 haplotype (as predicted from linkage disequilibria, 14.6% vs. 1.5%, P = .009; odds ratio [OR] = 11.3; 95% confidence interval [CI] 1.3-252.7): 6 patients with CD carried HLA-DRB1(*)03, 1 carried an HLA-DRB1(*)04 allele, and 1 had an HLA-DRB1(*)07/(*)11 genotype.
|
26121457 |
2015 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, no statistically significant differences were observed after stratifying patients for DRB1*03- or GD-associated variants in CTLA4 or TSHR genes.
|
24289805 |
2014 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical value of human leukocyte antigen HLA-DRB1 subtypes associated to Graves' disease in Romanian population.
|
24661105 |
2014 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a direct comparison between GD and HT, we identified GD-specific susceptible class II molecules, HLA-DP5 (HLA-DPB1*05:01; Pc = 1.0 × 10(-9)) and HLA-DR14 (HLA-DRB*14:03; Pc = .0018).
|
24285682 |
2014 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The carriers of the HLA DRB1*03 allele were more frequent in patients with age at GD diagnosis ≤30 years than in patients with older age at GD diagnosis.
|
23544060 |
2013 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results clearly identify that HLA-DRB1*09:01 confers susceptibility to GD and DRB1*12:02 exerts protection against GD development in Taiwanese children.
|
22731780 |
2012 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combining the data of two sample populations, we found that B*46:01 (odds ratio under dominant model [OR] = 1.33, Bonferroni corrected combined P [P(Bc)] = 1.17 x 10⁻²), DPB1*05:01 (OR = 2.34, P(Bc) = 2.58 x 10⁻¹⁰), DQB1*03:02 (OR = 0.62, P(Bc) = 1.97 x 10⁻²), DRB1*15:01 (OR = 1.68, P(Bc) = 1.22 x 10⁻²) and DRB1*16:02 (OR = 2.63, P(Bc) = 1.46 x 10⁻⁵) were associated with GD.
|
21307958 |
2011 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of HLA-DRB1 alleles associated with Graves' disease in Koreans by sequence-based typing.
|
21062236 |
2011 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there is increasing evidence for a genetic interaction between thyroglobulin variants and DRb1-Arg74 in conferring risk for GD.
|
18178059 |
2008 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1(*)03-DQB1(*)02-DQA1(*)05) and a protective effect for DR7 (DRB1(*)07-DQB1(*)02-DQA1(*)02).
|
18449200 |
2008 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1(*)03-DQB1(*)02-DQA1(*)05) and a protective effect for DR7 (DRB1(*)07-DQB1(*)02-DQA1(*)02).
|
18449200 |
2008 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequencies of DRB1*03 was significantly increased in GD compared to controls (OR = 2.07; 95% CI = 1.24-3.44), whereas DRB1*13 (OR = 0.33; 95% CI = 0.18-0.61) and DRB1*07 (OR = 0.31; 95% CI = 0.13-0.70) were significantly increased in controls compared to patients.
|
17284224 |
2007 |
|
Graves Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect.
|
17597093 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The members of maternal pedigree including both affected and unaffected Graves' disease had haplotypes of DRB1*150101 and DQB1*0602, except for the cousin who had DRB1*140301 and DQB1*030101.
|
17785916 |
2007 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.
|
16756466 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease.
|
16646680 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, DRB1*1602 allele and closely linked haplotype, DRB1*1602-DQA1*0102-DQB1*0502, might serve as a marker for genetic susceptibility to GD in Asian population.
|
16451208 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, others are more disease specific (HLA-DRB1*11 for systemic sclerosis and HLA-DRB1 alleles encoding the "shared epitope" in RA) as well as non MHC genes, such as FcyRIIa and IIIa in SLE, the beta2 glycoprotein I gene in the aPL syndrome, and the TSHR gene in Graves' disease).
|
16890892 |
2006 |
|
Graves Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We detected association of rs2076530 within a large GD dataset [OR = 1.32 (95% CI = 1.14-1.52)], however, linkage disequilibrium (LD) analysis revealed association of rs2076530 to be secondary to the previously established DRB1 exon 2 encoded position beta74 effect although a rare haplotype effect, including both loci, cannot be excluded.
|
16984233 |
2006 |