|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GWAS identified independent associations of HLA-DRB1-DQB1, HLA-DPB1 and BTNL2 genes with immune response to a HB vaccine designed based on the HBV genotype C. Five HLA-DRB1-DQB1 haplotypes and two DPB1 alleles showed significant associations with response to the HB vaccine in a comparison of three groups of 1,193 HB vaccinated individuals.
|
29534301 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The univariate analysis performed revealed significant association of the HLA-DRB1*03 and HLA-DQB1*05 alleles to the infected persons (study group), while HLA-DRB1*01 was shown to be protective against HBV infection.
|
29979894 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th2 cytokine expression was high in HLA-DRB1*03 positive (+) HBV patients, with low Th1 cytokine levels.
|
30045250 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicated that HLA-B*44:03, C*07:01, DQB1*02:02 and DRB1*07:01 were related to OBI infection, whereas HLA-DRB1*08:03, DRB1*15:01 and DQB1*06:02 alleles were associated with HBV DNA clearance in a Shaanxi Han population.
|
28940887 |
2017 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results revealed that A*02-DRB1*12 and A*02-B*15-DRB1*09 carriers were susceptible to HBV infection.
|
25592155 |
2015 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Characterization and genotyping of the DRB1 gene of the major histocompatibility complex (MHC) in the Marmota monax, animal model of hepatitis B.
|
25458311 |
2015 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis.
|
26538132 |
2015 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover the relation between HLA-DRB1 allelic groups and hepatitis B, hepatitis C and cytomegalovirus viral infections was also studied.
|
24903971 |
2014 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness.
|
22499074 |
2012 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*15, DRB1*11 and 14 associated with viral clearance in the cases of HBV-C2 infection; HLA-B*54 carriers in chronic group are more sensitive to with the infection of HBV subgenotype B2; HLA-B*07 and DRB1*13 may protect subjects from HBV infection.
|
22056847 |
2012 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of LA-DRB1*03 in the CHB patient group was significantly higher compared to that in the asymptomatic hepatitis B carrier patients.
|
22367481 |
2012 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus.
|
19235869 |
2009 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus.
|
19235869 |
2009 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
After controlling for pre-booster anti-HBs levels, the absences of HLA-A*02 and -DRB1*08, simply expressed as A*02(-) and -DRB1*08(-), and the presence of B*15 were significantly associated with elevated risks of non-response (post-booster anti-HBs titers<10 mIU/mL) to booster vaccination.
|
18501999 |
2008 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*07, is associated with the susceptibility of the infants to intrauterine HBV infection.
|
18463715 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Beninese origin and HLA-DRB1*09 allele were the other determinants independently associated with favorable outcome of HBV infection.
|
18222012 |
2008 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-A*33 was closely related with susceptibility to persisting hepatitis B infection, and HLA-DRB1*13 was closely related with protection against persisting hepatitis B in an Iranian population.
|
18761557 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the association between HBV infection and HLA-DRB1 alleles in Han individuals in northwestern China was studied for the first time.
|
17257320 |
2007 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population.
|
17465466 |
2007 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
LHGDN |
Association of human leukocyte antigen polymorphism with hepatitis B virus infection and genotypes.
|
17186951 |
2006 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, common African HLA-DRB1 and -DQB1 variants, previously associated with protection from malaria and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection.
|
16916662 |
2006 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
LHGDN |
The association of HLA-DR13 with lower graft survival rates in hepatitis B and primary sclerosing cholangitis Caucasian patients receiving a liver transplant.
|
16555323 |
2006 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment.
|
16237774 |
2005 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of the allele of HLA-DR12 DRB1*1201 was higher in the subjects recovered from hepatitis B infection (32%) than in the patients with chronic hepatitis B (3%; rr, 0.07; Pcorr<0.005).
|
14599975 |
2003 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
For chronic HBV infection per se, DRB1*1302, DQB1*0402, and DQB1*0604 had some protective effect (OR = 0.4, OR = 0.3, and OR = 0.1, respectively), and DRB1*1101 was weakly associated (OR = 4.6) in Koreans.
|
14617034 |
2003 |