|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.
|
29270995 |
2018 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Meanwhile, HLA-DRB-1*15:02, DQA-1*01:03, DQB-1*06:01, and DPB-1*09:01 as HLA class II were positively associated with IBD-TA (P = 0.004, P = 0.019, P = 0.019, and P = 0.002, respectively).
|
28449344 |
2017 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
However, the role of HLA-DRB1 locus on the susceptibility to develop CRC tumor, in the absence of a history of inflammatory bowel diseases (IBDs), is unclear.
|
25346274 |
2015 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
|
25559196 |
2015 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In contrast, small duct PSC without IBD was only associated with HLA-DRB1*13:01(P = 0.03) and was otherwise distinctly dissimilar from large duct PSC.
|
24517468 |
2014 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Recently, numerous new genes have been identified as being involved in the genetic susceptibility to IBD: TNF-308A, CARD15 (NOD2), MIF-173, N-acetyltransferase 2 (NAT2), NKG2D (natural killer cell 2D), STAT6 (signal transducer and activator of transcription 6), CTLA-4 (cytotoxic T lymphocyte antigen-4), MICA-MICB (major histocompatibility complex A and B), HLA-DRB1, HLA class-II, IL-18, IL-4, MICA-A5, CD14, TLR4, Fas-670, p53 and NF-kappaB.
|
19230040 |
2009 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
|
18758464 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
GWASDB |
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
|
18758464 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population.
|
18338763 |
2008 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In this study, we performed a case-control association study of BTNL2 in the Japanese patients with IBD and performed linkage disequilibrium (LD) analysis between BTNL2 and HLA-DRB1.
|
17610417 |
2007 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our aim was to study the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 in patients with UC and CD, respectively.
|
17389014 |
2007 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
HLA-DRB1 alleles may influence disease phenotype in patients with inflammatory bowel disease: a critical reappraisal with review of the literature.
|
15690658 |
2005 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
This appears to be true for both inflammatory bowel diseases as HLA-DRB1*0103 is associated both with colonic Crohn's disease and ulcerative colitis.
|
15626888 |
2004 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In the non-Jewish IBD families, IBD was as strongly associated with the DRB1*0103 DQB1*0501 haplotype as with the DRB1*0103 allele alone.
|
12656131 |
2003 |
|
Inflammatory Bowel Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The more common DR1 haplotype, DRB1*0103-DQA1*0101-DQB1*0501, was also associated with IBD (OR = 3.1, p = 0.014), a result suggesting that interaction between DR and DQ may determine the extent of disease risk.
|
10689124 |
2000 |
|
Inflammatory Bowel Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
IBD-AS was associated only with HLA-B*27 and DRB1*0101.
|
10648455 |
2000 |