|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, DRB1*14 was demonstrated to be a second independent variants (P = 4.2 × 10<sup>-63</sup> , OR = 35.47) for PV, while DRB1*04:06 was demonstrated to be the second independent signal (P = 7.44 × 10<sup>-13</sup> , OR = 5.58) for PF.
|
30169916 |
2019 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
HLA-DQB1*05:03 ranks at the top (P = 4·7 × 10<sup>-40</sup> ; odds ratio 12·4) in both subtypes, with significantly different risk allele frequency (RAF<sub>PV</sub> = 34·2% vs. RAF<sub>PF</sub> = 18·8% vs. RAF<sub>control</sub> = 4·4%), whereas HLA-DRB1*14:01 and HLA-DRB1*04:06 are PV specific.
|
30230522 |
2019 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
There was a significant association between HLA-DRB1*14 and HLA-DQB1*05 and pemphigus vulgaris in our patients.
|
29582787 |
2018 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A fine-mapping analysis of PV risk in the major histocompatibility complex region showed three independent variants predisposed to PV using stepwise analysis: HLA-DRB1*14:04 (P = 2.47 × 10<sup>-38</sup>, odds ratio = 6.28), rs7454108 at the TAP2 gene (P = 2.78 × 10<sup>-12</sup>, odds ratio = 3.25), and rs1051336 at the HLA-DRA gene (P = 3.06 × 10<sup>-6</sup>, odds ratio = 0.33).
|
29857070 |
2018 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients that carry both the PV-associated human leukocyte antigen (HLA) alleles DRB1*0402 and DQB1*0503, or DQB1*0503 alone show a low prevalence of anti-TPO (A.R.
|
29675021 |
2018 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is a close immunogenetic association of PV with the human leukocyte antigen (HLA) class II alleles, HLA-DRB1*04:02 and HLA-DQB1*05:03.
|
29313220 |
2018 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:02 and DQB1*05:03 alleles are associated with pemphigus vulgaris in our study as well as in various populations.
|
28197992 |
2017 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, while <i>HLA-DRB1*04:02</i> confers susceptibility to PV, this and other alleles that encode the same sequence motif in the 70-74 region of the DR beta chain are protective against RA.
|
27814654 |
2017 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Subjects were typed for HLA class II DRB1 and DQB1 alleles, and categorized as HLA-matched if homozygous or heterozygous for either one of the known PV-susceptibility alleles, DRB1*0402 and DQB1*0503.
|
28174139 |
2017 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
DRB1*04:02, DRB1*14:04, DQB1*03:02 and DQB1*05:03 alleles were shown to be strongly associated with PV (P adj = 1.63 × 10(-12), 5.20 × 10(-7), 1.28 × 10(-6), and 4.44 × 10(-5), respectively).
|
27072514 |
2016 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
Their parents and five siblings had only one or none of these two haplotypes in combination with the alleles or haplotypes associated with resistance to PV (DRB1∗07:01-DQA1∗02:01-DQB1∗02:02 and DRB1∗13:01-DQA1∗01:03-DQB1∗06:03).
|
27177496 |
2016 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taking advantage of an area where pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are prevalent in the northeastern region of the state of São Paulo, Southeastern Brazil, we have studied the HLA class I (A, B and C) and class II (DRB1 and DQA1/DQB1) profiles in 86 and 83 patients with PF and PV, respectively, as compared with 1592 controls from the same region.
|
27178774 |
2016 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HLA DRB1* and DQB1* alleles influence susceptibility to PV and may contribute to PV severity and type.
|
24602055 |
2015 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show that CD4(+) T cells recognizing immunodominant Dsg3 epitopes in the context of the PV-associated HLA-DRB1*04:02 induce the secretion of Dsg3-specific IgG in vivo.
|
25252957 |
2014 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
The occurrence of PV is positively associated with HLA-DRB1*14 and HLA-DRB1*0402 but negatively associated with HLA-DRB1*11 in the Syrian population.
|
24697292 |
2014 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
We confirmed the previously reported associations between HLA class II alleles and PV and described a new association between PV and DRB1*14:54.
|
23551624 |
2013 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that DRB1*04, DRB1*08 and DRB1*14 are statistically significant susceptibility factors for PV.
|
22564118 |
2012 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Population-specific association between a polymorphic variant in ST18, encoding a pro-apoptotic molecule, and pemphigus vulgaris.
|
22437316 |
2012 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that an HLA-DRB1*1405 (DQB1*0503) haplotype may confer susceptibility to both PV and PF, and that genetic susceptibility alone is not always responsible for the clinical phenotype and autoantibody profile.
|
21352303 |
2011 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that HLA DRB1*04 and DRB1*14 alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic markers for general susceptibility to PV in the Turkish population.
|
20507388 |
2010 |
|
Pemphigus Vulgaris
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Genetic factors are involved in the occurrence of PV; HLA-DRB1*04 and -DRB1*1401 alleles and the related haplotypes are suggestive to be two major PV susceptibility factors in our population study.
|
18780165 |
2009 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results support the hypothesis that the DRB1*0402 without DQB1*0302 is the most relevant HLA-DRB1 allele responsible for the pathogenesis of pemphigus in Venezuelan patients with PV and discard the DQB1*0302 influence observed in other populations.
|
17389015 |
2007 |
|
Pemphigus Vulgaris
|
0.200 |
Biomarker
|
disease |
BEFREE |
Studies showed that the associated HLA haplotype in Jewish pemphigus vulgaris (PV) patients is HLA-B38, DRB1*0402, and DQB1*0302; or HLA-B35, DRB1*0402, and DQB1*0302.
|
15009804 |
2004 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The DR and DQ molecular alleles positively associated with PV were two different haplotypes: DRb1* 0402/DQb1* 0302 and DRb1* 1401/DQb1* 0503.
|
12196893 |
2003 |
|
Pemphigus Vulgaris
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Dsg3-specific T-cell responses were detected in PV patients but also in healthy individuals who were either carriers of the PV-associated DRB1*0402 allele or alleles that share similar or identical peptide binding motifs to DRB1*0402.
|
12878355 |
2003 |