|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups.
|
30516034 |
2019 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The recent meta-analysis studies revealed the association of several HLA alleles in particular class II HLA-DRB1 with TB susceptibility and valuable marker for disease development especially in Asian populations.
|
30167433 |
2018 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mycobacterium tuberculosis peptide E7/HLA-DRB1 tetramers with different HLA-DR alleles bound CD4<sup>+</sup> T cells might share identical CDR3 region.
|
29967390 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA association analysis of patients infected with modern MTB strains showed significant association for HLA-DRB1*09:01 (odds ratio [OR] = 1.82; P-value = 9.88 × 10<sup>-4</sup> ) and HLA-DQB1*03:03 alleles (OR = 1.76; P-value = 1.31 × 10<sup>-3</sup> ) with susceptibility to TB.
|
28612994 |
2017 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis showed that both ethnicity and genotyping method affected the association between HLA-DRB1*03, HLA-DRB1*04 and HLA-DRB1*08 alleles and TB occurrence.
|
26688538 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group.
|
27788190 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These HLA-DRB1*09:01-restricted CD4<sup>+</sup> T-cell epitopes facilitate analysis of the role of 38 kDa- and Ag85A-specific T cells in MTB infection and pave way for the design of vaccines against tuberculosis.
|
27861807 |
2016 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found association of three variants in the region harboring genes encoding the class II human leukocyte antigens (HLAs): rs557011[T] (minor allele frequency (MAF) = 40.2%), associated with M. tuberculosis infection (odds ratio (OR) = 1.14, P = 3.1 × 10(-13)) and PTB (OR = 1.25, P = 5.8 × 10(-12)), and rs9271378[G] (MAF = 32.5%), associated with PTB (OR = 0.78, P = 2.5 × 10(-12))--both located between HLA-DQA1 and HLA-DRB1--and a missense variant encoding rs9272785;rs386699558" genes_norm="3117">p.Ala210Thr in HLA-DQA1 (MAF = 19.1%, rs9272785), associated with M. tuberculosis infection (P = 9.3 × 10(-9), OR = 1.14).
|
26829749 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility.
|
26634553 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, the results also show no significant association between HLA-DRB1*01 (P = 0.748), *03 (P = 0.947), *07 (P = 0.966), *08 (P = 0.440), *12 (P = 0.288), *13 (P = 0.241), and *14 (P = 0.551) gene polymorphisms and TB risk.
|
25787085 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*1501 and VDR polymorphisms and survival of Mycobacterium tuberculosis in human macrophages exposed to inhalable microparticles.
|
23556450 |
2013 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the NRAMP1 gene, VDR gene, HLA-DRB1 gene, and HLA-DQB1 gene are statistically associated with susceptibility to TB in the Chinese Kazakh population.
|
24024195 |
2013 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, HLA-DRB1*14 was more frequent in TB patients suggesting that it may be involved in the evolution infection towards active TB in our population.
|
21251479 |
2011 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the familial aggregation of tuberculosis using relatedness and a specific inherited marker (HLA-DRB1) was evaluated.
|
19692729 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that these less-protective DRB1 alleles are found at a very high frequency in several populations with a high burden of tuberculosis.
|
20353587 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
When tested at an affinity level equivalent of the 1% of the best binder peptides, the HLA-DR alleles (HLA-DRB1*0801, *0802, *1401, *1501 and *1502) associated with TB susceptibility recognized a significantly lower mean number of MTB-epitopes (7,862 +/- 4,258) than the MTB-epitopes recognized by HLA-DR alleles (HLA-DRB1*0301, *0701, *1101, *1102, *1301 and *1302) negatively associated with TB (11,376 +/- 1,984, p<0.032).
|
19070257 |
2008 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used the polymerase chain reaction with sequence specific primer method to study the DRB1* locus in 147 Syrian patients with positive sputum smear or sputum culture for Mycobacterium Tuberculosis strains, and 209 Syrian healthy matching individuals with negative tuberculin skin test.
|
18998014 |
2008 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-A31 and HLA-B41 antigens and the HLA-DRB1*10 and HLA-DQB1*05 alleles were over-represented in patients with AIDS and tuberculosis (Group I), suggesting that these HLA molecules are associated with susceptibility to tuberculosis in Brazilian patients with AIDS.
|
19030725 |
2008 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When tested at an affinity level equivalent of the 1% of the best binder peptides, the HLA-DR alleles (HLA-DRB1*0801, *0802, *1401, *1501 and *1502) associated with TB susceptibility recognized a significantly lower mean number of MTB-epitopes (7,862 +/- 4,258) than the MTB-epitopes recognized by HLA-DR alleles (HLA-DRB1*0301, *0701, *1101, *1102, *1301 and *1302) negatively associated with TB (11,376 +/- 1,984, p<0.032).
|
19070257 |
2008 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study suggests that HLA-DRB1 alleles differentially modulate the various cytokine responses to M. tuberculosis antigens, which may influence the cellular and humoral immune responses to M. tuberculosis infection in a susceptible host.
|
17826339 |
2007 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, common African HLA-DRB1 and -DQB1 variants, previously associated with protection from malaria and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection.
|
16916662 |
2006 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that DRB1*0803 and DQB1*0601 alleles are associated with disease progression of TB in Koreans, exerting influence on the development of drug resistance, severe disease, and recurrent disease.
|
16386650 |
2005 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It seems likely that the presence of DRB1*1601, DQB1*0502 alleles and DRB1*1601-DQB1*0502, DRB1*04-DQB1*03, DRB1*14-DQB1*05 haplotypes may be related to a higher risk of developing TB, whereas low frequency of DQB1*0201 and DRB1*11-DQB1*03 haplotype may be linked to the resistance to TB.
|
15958261 |
2005 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1 homozygosity among HIV-positive subjects was associated with reduced risk of developing pulmonary TB but increased risk of rapid progression to pleural effusion TB.
|
14999612 |
2004 |