|
Superficial ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, stratified analyses indicated statistically significant associations between HLA-DRB1*04 allele and anti-cyclic peptides antibodies positivity (ACPA(+)) and rheumatoid factor positivity (RF(+); p(c)=0.03, for both subgroups), HLA-DRBI*10 and ACPA(+) and the presence of another autoimmune disease (p(c)=0.05 and p(c)=0.007, respectively), and HLA-DRB1*04:05 and RF(+) and erosion (p(c)=0.005 and p(c)=0.049; respectively).
|
22349877 |
2012 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the value of HLA-DRB1 shared epitope (SE), -308 tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphism, rheumatoid factor (RF), anti-citrullinated peptide antibodies (anti-CCP), and baseline erosions for predicting radiological outcome at 1 year in patients with recent-onset rheumatoid arthritis (RA).
|
19411391 |
2009 |
|
Superficial ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rheumatoid factor positivity and bone erosion were more frequent in patients with at least one copy of DRB1*0405.
|
17309132 |
2007 |
|
Superficial ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies against cyclic citrullinated peptide are associated with the DRB1 shared epitope and predict joint erosion in rheumatoid arthritis.
|
16728439 |
2007 |
|
Superficial ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the relationship between the HLA-DRB1 genes with disease severity as assessed by radiological erosions in Malaysian patients with rheumatoid arthritis (RA).
|
17453717 |
2007 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Included were studies in which molecular typing of HLA-DRB1 alleles was performed and in which the presence or absence of bony erosions was reported.
|
14872482 |
2004 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases.
|
15124939 |
2004 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles did not show any association with seropositivity, extra-articular involvement, radiological erosion, or functional index.
|
14690140 |
2003 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the association between HLA-DRB1 alleles and shoulder destruction due to rheumatoid arthritis (RA) in Japanese, we typed for HLA-DRB1 alleles in 100 Japanese RA patients who could be classified into 5 groups: non-progressive (N) with normal radiographs; erosive (E) showing marginal erosion but no collapse; collapse (C) showing subchondral cysts followed by collapse; arthrosis-like (A) showing osteoarthrotic features; and the mutilating (M) showing mutilating bone destruction.
|
9572642 |
1998 |
|
Superficial ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*0405 is associated with the presence of extraarticular features and erosions in Singaporean Chinese patients with RA.
|
9101492 |
1997 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the DRB1 alleles or SE genotypes correlated with the presence of bone erosion at presentation or 1 year later.
|
9416863 |
1997 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the most common RA susceptibility allele, HLA-DRB1*0405, is significantly associated with bony erosion, joint deformity and extra-articular manifestations.
|
9159536 |
1997 |
|
Superficial ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant correlation of DRB1 genotypes was found with severity of RA as judged by nodules or articular erosions.
|
8977961 |
1996 |