Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 Biomarker disease BEFREE Among direct targets, hijacking an HLF binding site in a MYC enhancer cluster by TCF3-HLF activates a conserved MYC-driven transformation program crucial for leukemia propagation in vivo. 31735627 2019
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 Biomarker disease BEFREE Intriguingly, TCF3 (E2A)-HLF-positive leukemia was sensitive to PARP inhibitors. 27894958 2017
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 AlteredExpression disease BEFREE Hypoxia or HLF expression reversed the oxidative stress, rescuing leukemia development in Meis1-deficient cells. 25740828 2015
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 AlteredExpression disease BEFREE Since the E2A, PBX1 and HLF proteins all appear to function as transcription factors, it appears likely that the oncogenic fusion proteins contribute to leukemia development by causing abnormal transcriptional regulation of key target genes. 12700034 2003