|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The differences in signaling pathway characteristics under sorafenib treatment between HCC (HLF, Huh7, PLC/PRF/5) and CCC (RBE, YSCCC, Huh28) cell lines were therefore investigated using cell proliferation, western blotting, and apoptosis analyses.
|
29251327 |
2018 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We compared the overall gene expression profile of poorly-differentiated (HLE, HLF, SNU-449) to well-differentiated (HUH7, HEPG2, HEP3B) HCC cell lines in three publicly available microarray datasets.
|
30176945 |
2018 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
To explore the role of ITGB4 in HCC, we inhibited its expression using small interfering RNA in two HCC cell lines: HCCLM3 and HLF.
|
26996299 |
2016 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Similarly, modulation of Smad7 expression changed the sensitivity of Huh7, FLC-4, HLE and HLF HCC cell lines for cytostatic TGF-β effects.
|
25602745 |
2015 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
We show, across multiple murine (P2E and P2M) and human HCC cell lines (Huh7, PLC/PRF/5, HLE, and HLF), that the TGFβ signaling axis is a conserved driver of mesenchymal phenotype HCC and confirm that Wnt and SHH signaling are induced in these cell lines.
|
25189528 |
2014 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
First, two 5-FU-resistant cell lines, HLF-R4 and HLF-R10, were established from the HLF undifferentiated human HCC cell line.
|
22179686 |
2012 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
5-FU had synergistic effect on TRAIL in HLF and additive effect in four other HCC cell lines.
|
15585621 |
2004 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we examined Snail and E-cadherin mRNA/protein expression in five hepatocellular carcinoma cell lines with variable phenotypes (HuL-1, Hep-G(2), Changliver, HLE, and HLF).
|
11857019 |
2002 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The expression of nine oncogenes (c-myc, N-myc, N-ras, H-ras, k-ras, abl, fos, src, and raf) and two tumor suppressor genes (p53 and RB) were studied by northern blot hybridization in six human hepatocellular carcinoma or hepatoblastoma cell lines (PLC/PRF/5, Hep3B, Hep G2, 2.2.15, HLE, and HLF) and in a human embryonic lung fibroblast cell line (WI-38) to look for differences that might be associated with the presence (PLC/PRF/5, Hep3B, and 2.2.15) or absence (Hep G2, HLE, and HLF) of integrated hepatitis B virus (HBV) DNA.
|
1335479 |
1992 |