|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The histone acetyltransferase EP300 regulates TCF3-HLF, which promotes acute lymphoblastic leukemia.
|
31757791 |
2020 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
t(17;19)(q21-q22;p13), responsible for TCF3-HLF fusion, is a rare translocation in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL). t(1;19)(q23;p13), producing TCF3-PBX1 fusion, is a common translocation in childhood BCP-ALL.
|
31305009 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The chimeric transcription factor TCF3-HLF defines an incurable acute lymphoblastic leukemia subtype.
|
31735627 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
|
26214592 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
|
26214592 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.
|
22743623 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A novel TCF3-HLF fusion transcript in acute lymphoblastic leukemia with a t(17;19)(q22;p13).
|
23181981 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
|
17183364 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
ABCB1 over-expression and drug-efflux in acute lymphoblastic leukemia cell lines with t(17;19) and E2A-HLF expression.
|
16206189 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia.
|
16531271 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia].
|
16215946 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The t(17;19)(q21-q22;p13.3) in acute lymphoblastic leukemia results in creation of an E2A-HLF fusion protein with structural and functional properties of a chimeric transcription factor.
|
8180393 |
1994 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia.
|
7518549 |
1994 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report that the t(17;19) in acute lymphoblastic leukemia produces a chimeric transcription factor consisting of the amino-terminal portion of HLH proteins E12/E47 (products of the E2A gene) fused to the basic DNA-binding and leucine zipper dimerization motifs of a novel hepatic protein called hepatic leukemia factor (Hlf).
|
1516826 |
1992 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
Biomarker
|
disease |
BEFREE |
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
|
29334255 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
The oncogenic fusion protein E2A-HLF is a chimeric transcription factor that arises from the t(17;19) translocation in childhood B-cell acute lymphoblastic leukemias (B-precursor ALL) and is associated with very poor outcome.
|
21072044 |
2011 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
Biomarker
|
disease |
BEFREE |
Transfection of E2A-HLF into a non-t(17;19) B-precursor ALL cell line induced LMO2 gene expression that was dependent on the DNA-binding and transactivation activities of E2A-HLF.
|
20519628 |
2010 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
FusionGene
|
disease |
ORPHANET |
Transfection of E2A-HLF into a non-t(17;19) B-precursor ALL cell line induced LMO2 gene expression that was dependent on the DNA-binding and transactivation activities of E2A-HLF.
|
20519628 |
2010 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The E2A-HLF oncoprotein arises from a t(17;19) translocation in childhood pro-B cell acute lymphoblastic leukaemia and acts as an anti-apoptotic factor in FL5.12 and Baf-3 cells.
|
15147370 |
2004 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
In pro-B cell acute lymphoblastic leukemia (ALL), expression of the E2A-HLF fusion gene as a result of t(17;19)(q22;p13) is associated with poor prognosis, hypercalcemia, and hemorrhagic complications.
|
15070701 |
2004 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
Biomarker
|
disease |
BEFREE |
The E2A-HLF fusion gene transforms human pro-B lymphocytes by interfering with an early step in apoptotic signaling.
|
10518215 |
1999 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The 'promiscuous' E2A gene, at 19p13.3, is fused with two different molecular partners, PBX1 and HLF, following two chromosome translocations recurrent in childhood pre-B ALL.
|
10086727 |
1999 |
|
Precursor B-cell lymphoblastic leukemia
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The E2A-HLF fusion gene, formed by a t(17;19)(q22;p13) in childhood pro-B-cell acute lymphoid leukemia, encodes a hybrid protein that contains the trans-activation domain of E2A (E12/E47) linked to the bZIP DNA-binding and dimerization domain of hepatic leukemia factor (HLF).
|
8164688 |
1994 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.360 |
Biomarker
|
disease |
BEFREE |
To determine whether methylation differences between mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes can be associated with differential gene expression and remission.
|
29334255 |
2018 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.360 |
Biomarker
|
disease |
BEFREE |
In addition, it is of note that viral integration and overexpression of the Zfp521 gene was detected in one tumor with B-cell lineage; we previously identified Zfp521 as a cooperative gene with E2A-HLF, another E2A-involving fusion gene with B-lineage ALL.
|
27088431 |
2016 |